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TAXT, T. JIŘÍK, R. RYGH, C. GRÜNER, R. BARTOŠ, M. ANDERSEN, E. CURRY, F. REED, R.
Original Title
Single-channel blind estimation of arterial input function and tissue impulse response in DCE-MRI.
Type
journal article in Web of Science
Language
English
Original Abstract
Multipass dynamic MRI and pharmacokinetic modeling are used to estimate perfusion parameters of leaky capillaries. Curve fitting and nonblind deconvolution are the established methods to derive the perfusion estimates from the observed arterial input function (AIF) and tissue tracer concentration function. These nonblind methods are sensitive to errors in the AIF, measured in some nearby artery or estimated by multichannel blind deconvolution. Here, a single-channel blind deconvolution algorithm is presented, which only uses a single tissue tracer concentration function to estimate the corresponding AIF and tissue impulse response function. That way, many errors affecting these functions are reduced. The validity of the algorithm is supported by simulations and tests on real data from mouse. The corresponding nonblind and multichannel methods are also presented.
Keywords
Perfusion, DCE-MRI, blind deconvolution, arterial input function, single-channel, multi-channel
Authors
TAXT, T.; JIŘÍK, R.; RYGH, C.; GRÜNER, R.; BARTOŠ, M.; ANDERSEN, E.; CURRY, F.; REED, R.
RIV year
2012
Released
1. 4. 2012
ISBN
0018-9294
Periodical
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Year of study
59
Number
4
State
United States of America
Pages from
1012
Pages to
1021
Pages count
10
BibTex
@article{BUT94726, author="Torfinn {Taxt} and Radovan {Jiřík} and Cecilie Brekke {Rygh} and Renate {Grüner} and Michal {Bartoš} and Erling {Andersen} and Fitz-Roy {Curry} and Rolf {Reed}", title="Single-channel blind estimation of arterial input function and tissue impulse response in DCE-MRI.", journal="IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING", year="2012", volume="59", number="4", pages="1012--1021", issn="0018-9294" }