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LÍZAL, F. JEDELSKÝ, J. ADAM, J. BĚLKA, M. JÍCHA, M.
Original Title
Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs
Type
conference paper
Language
English
Original Abstract
Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.
Keywords
aerosol transport, aerosol deposition, positron emission tomography, human lung model
Authors
LÍZAL, F.; JEDELSKÝ, J.; ADAM, J.; BĚLKA, M.; JÍCHA, M.
RIV year
2012
Released
9. 4. 2013
Publisher
EDP Sciences
Location
Francie
ISBN
978-80-7372-912-7
Book
EPJ Web of Conferences
2100-014X
Periodical
Year of study
45
Number
1
State
French Republic
Pages from
Pages to
4
Pages count
URL
https://www.epj-conferences.org/articles/epjconf/abs/2013/06/epjconf_efm2013_01060/epjconf_efm2013_01060.html
Full text in the Digital Library
http://hdl.handle.net/11012/193652
BibTex
@inproceedings{BUT95329, author="František {Lízal} and Jan {Jedelský} and Jan {Adam} and Miloslav {Bělka} and Miroslav {Jícha}", title="Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs", booktitle="EPJ Web of Conferences", year="2013", journal="EPJ Web of Conferences", volume="45", number="1", pages="1--4", publisher="EDP Sciences", address="Francie", doi="10.1051/epjconf/20134501060", isbn="978-80-7372-912-7", issn="2100-014X", url="https://www.epj-conferences.org/articles/epjconf/abs/2013/06/epjconf_efm2013_01060/epjconf_efm2013_01060.html" }