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STIBOROVÁ, M. ECKSCHLAGER, T. POLJAKOVÁ, J. HRABĚTA, J. ADAM, V. KIZEK, R. FREI, E.
Original Title
The Synergistic Effects of DNA-Targeted Chemotherapeutics and Histone Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatment
Type
journal article in Web of Science
Language
English
Original Abstract
Histone deacetylase (HDAC) inhibitors are a group of anticancer drugs which cause growth arrest and apoptosis of several tumor cells. HDAC inhibitors have been also found to increase the anticancer efficacy of several treatment modalities i.e. chemotherapy or radiotherapy. Here, we review the literature on combinations of HDAC inhibitors both with ionizing radiation and with other drugs, highlighting DNA-damaging compounds. The results of numerous studies with several types of cancer cells discussed in this review demonstrate that HDAC inhibitors enhance the effect of DNA damaging agents, such as inhibitors of topoisomerases, inhibitors of DNA synthesis, DNA-intercalators and agents covalently modifying DNA (i.e. doxorubicin, etoposid, 5-fluorouracil, cisplatin, melphalan, temozolomide and ellipticine) or of irradiation. Hence, the use of HDAC inhibitors combined with these antitumor drugs or ionizing radiation is a promising tool which may make treatment of patients suffering from many types of cancer more efficient. Several molecular mechanisms are responsible for the observed higher sensitivity of tumor cells towards therapeutic agents elicited by HDAC inhibitors. These mechanisms are discussed also in this review
Keywords
Chromatin remodeling; histone acetylation; histone deacetylase; histone deacetylase inhibitor; anticancer drugs; DNA-damaging drugs; ionizing radiation; combined treatment modalities; mechanisms of combined treatment; apoptosis
Authors
STIBOROVÁ, M.; ECKSCHLAGER, T.; POLJAKOVÁ, J.; HRABĚTA, J.; ADAM, V.; KIZEK, R.; FREI, E.
RIV year
2012
Released
1. 9. 2012
ISBN
0929-8673
Periodical
CURRENT MEDICINAL CHEMISTRY
Year of study
19
Number
25
State
United Arab Emirates
Pages from
4218
Pages to
4238
Pages count
21
BibTex
@article{BUT98898, author="Marie {Stiborová} and Tomáš {Eckschlager} and Jitka {Poljaková} and Jan {Hraběta} and Vojtěch {Adam} and René {Kizek} and Eva {Frei}", title="The Synergistic Effects of DNA-Targeted Chemotherapeutics and Histone Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatment", journal="CURRENT MEDICINAL CHEMISTRY", year="2012", volume="19", number="25", pages="4218--4238", issn="0929-8673" }