Publication detail

Bioactive Zirconia-Based Porous Scaffolds For Potential Bone Graft Applications

NOVOTNÁ, L. CIHLÁŘ, J.

Original Title

Bioactive Zirconia-Based Porous Scaffolds For Potential Bone Graft Applications

Type

conference paper

Language

English

Original Abstract

Alumina toughened zirconia (ATZ) / calcium phosphate (Ca-P) composite scaffolds were fabricated via polymer replica technique, the technique that best mimics the macrostructure of trabecular bone. Strong inert core based on ATZ was composed of microsized zirconia powder bonded by colloidal solution of boehmite. Sintered scaffolds were coated by suspension composed of hydroxyapatite / tricalcium phosphate powders and PVB binder. Scaffolds exhibited well-interconnected structure with pore sizes ranging from 300 to 1200 µm. Different porosity (50-98%) was achieved by repeating the replication process 1-6 times. The Ca-P coating with a thickness of about 50 µm was firmly adhered to the ATZ core. Neither of tested materials was cytotoxic. The apatite formation, appeared on the surface of coated scaffolds after immersion in simulated body fluid (SBF) indicated a good bioactivity of the ATZ/Ca-P composite.

Keywords

zirconia, Ca-phosphates, scaffold, template method

Authors

NOVOTNÁ, L.; CIHLÁŘ, J.

RIV year

2015

Released

28. 5. 2015

ISBN

978-80-214-5146-9

Book

Multi-scale Design of Advanced Materials - Conference Proceedings

Pages from

93

Pages to

99

Pages count

7

BibTex

@inproceedings{BUT114788,
  author="Lenka {Novotná} and Jaroslav {Cihlář}",
  title="Bioactive Zirconia-Based Porous Scaffolds For Potential Bone Graft Applications
",
  booktitle="Multi-scale Design of Advanced Materials - Conference Proceedings",
  year="2015",
  pages="93--99",
  isbn="978-80-214-5146-9"
}