Publication detail

Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival

Couvrat-Desvergnes, G. Salama, A. Le Berre, L Evanno, G. Viklicky, O. Hruba, P. Vesely, P. Guerif, P Dejoie, T. Rousse, J. Nicot, A. Bach, JM. Ang, E. Foucher, Y. Brouard, S. Castagnet, S. Giral, M. Harb, J. Perreault, H. Charreau, B. Lorent, M. Soulillou, JP

Original Title

Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival

Type

journal article in Web of Science

Language

English

Original Abstract

Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppressive agents during treatment of kidney allograft recipients. However, ATGs can induce immune complex diseases, including serum sickness disease (SSD). Rabbit and human IgGs have various antigenic differences, including expression of the sialic acid Neu5Gc and α-1-3-Gal (Gal), which are not synthesized by human beings. Moreover, anti-Neu5Gc antibodies have been shown to preexist and be elicited by immunization in human subjects. This study aimed to assess the effect of SSD on long-term kidney allograft outcome and to compare the immunization status of grafted patients presenting with SSD following ATG induction treatment.

Keywords

Rabbit antithymocyte globulin; serum sickness disease

Authors

Couvrat-Desvergnes, G.; Salama, A.; Le Berre, L; Evanno, G.; Viklicky, O.; Hruba, P.; Vesely, P.; Guerif, P; Dejoie, T.; Rousse, J.; Nicot, A.; Bach, JM. ; Ang, E.; Foucher, Y.; Brouard, S.; Castagnet, S.; Giral, M.; Harb, J.; Perreault, H.; Charreau, B.; Lorent, M.; Soulillou, JP

RIV year

2015

Released

1. 12. 2015

ISBN

0021-9738

Periodical

JOURNAL OF CLINICAL INVESTIGATION

Year of study

125

Number

12

State

United States of America

Pages from

4655

Pages to

4665

Pages count

11

BibTex

@article{BUT120517,
  author="Couvrat-Desvergnes, G. and Salama, A. and Le Berre, L and Evanno, G. and Viklicky, O. and Hruba, P. and Vesely, P. and Guerif, P and Dejoie, T. and Rousse, J. and Nicot, A. and Bach, JM. and Ang, E. and Foucher, Y. and Brouard, S. and Castagnet, S. and Giral, M. and Harb, J. and Perreault, H. and Charreau, B. and Lorent, M. and Soulillou, JP",
  title="Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival",
  journal="JOURNAL OF CLINICAL INVESTIGATION",
  year="2015",
  volume="125",
  number="12",
  pages="4655--4665",
  doi="10.1172/JCI82267",
  issn="0021-9738"
}