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HEJČ, J. RONZHINA, M. JANOUŠEK, O. OLEJNÍČKOVÁ, V. NOVÁKOVÁ, M. KOLÁŘOVÁ, J. STRAČINA, T.
Original Title
Response of Ventricular Repolarization Parameters to Preload Changes in the Isolated Working Heart
Type
conference paper
Language
English
Original Abstract
Heart rate dependency of ventricular repolarization (VR) parameters has been a well known phenomenon for many years. Other contributing factors, such as Mechano-electric Coupling, are still under investigation. In this work, we analyze step response of VR parameters after abrupt change in mechanical end-diastolic load. 10 isolated rabbit hearts were perfused in Working Heart mode. The protocol consisted of abrupt changes in preload level of 3 cmH2O. Left ventricle electric activity was recorded by seven unipolar leads at sampling frequency 10 kHz. A second-order transfer function model was used to identify basic parameters of QTEND and QTPEAK step responses, detected in reconstructed global pseudo-lead. Results show inverse relationship between changes in the preload and the length of QT related intervals. Increase of the preload causes significant (p<0.05) shortening of both intervals within the range of 1.6–26.9 ms. On the contrary, preload decreasing leads to prolongation of repolarization parameters, however, with significantly lower (p<0.05) average magnitude. Dynamic response is highly individual among each heart. Average time needed to reach stable QT in our data is 336.0 seconds, while min. and max. value is 41.4 and 894.0 seconds, respectively.
Keywords
QT interval, ventricular repolarization, ventricular load, preload, mechano-electric coupling, dynamic response, isolated heart, working heart
Authors
HEJČ, J.; RONZHINA, M.; JANOUŠEK, O.; OLEJNÍČKOVÁ, V.; NOVÁKOVÁ, M.; KOLÁŘOVÁ, J.; STRAČINA, T.
Released
30. 9. 2016
Publisher
Computing in Cardiology 2016
Location
Vancouver, Canada
ISBN
978-1-5090-0684-7
Book
Edition
43
Edition number
1
0276-6574
Periodical
Computers in Cardiology
State
United States of America
Pages from
409
Pages to
412
Pages count
4
URL
https://ieeexplore.ieee.org/document/7868766
BibTex
@inproceedings{BUT129890, author="Jakub {Hejč} and Marina {Filipenská} and Oto {Janoušek} and Veronika {Olejníčková} and Marie {Nováková} and Jana {Kolářová} and Tibor {Stračina}", title="Response of Ventricular Repolarization Parameters to Preload Changes in the Isolated Working Heart", booktitle="Computing in Cardiology 2016", year="2016", series="43", journal="Computers in Cardiology", number="1", pages="409--412", publisher="Computing in Cardiology 2016", address="Vancouver, Canada", isbn="978-1-5090-0684-7", issn="0276-6574", url="https://ieeexplore.ieee.org/document/7868766" }