Publication detail

Subtractive manufacturing of customized hydroxyapatite scaffolds for bone regeneration

TRUNEC, M. CHLUP, Z.

Original Title

Subtractive manufacturing of customized hydroxyapatite scaffolds for bone regeneration

Type

journal article in Web of Science

Language

English

Original Abstract

An approach to the preparation of customized hydroxyapatite scaffolds for bone regeneration based on subtractive manufacturing has been developed. The developed method is intended as a simple alternative to rapid prototyping based on additive manufacturing methods. The method for the preparation of customized scaffolds consists in computer numerical controlled (CNC) milling of porous hydroxyapatite foam. The machinable foam for customized scaffolds was prepared by direct foaming of a colloidal hydroxyapatite suspension and the foam structure was consolidated by the gelcasting method. The optimal foam after sintering reached a high porosity of 83.3% and the cellular-like structure contained spherical pores with an average diameter of 613 μm, which were connected through windows with an average diameter of 161 μm. The compressive strength of the sintered foam reached an average value of 2 MPa. CNC milling was tested at different stages of the production cycle of the porous foam and after the reinforcing of the foam by impregnation. The best results were obtained by milling the foam presintered at 1100 °C. The milling process was demonstrated and scaffold examples were successfully manufactured.

Keywords

milling, porosity, apatite, biomedical properties, scaffold

Authors

TRUNEC, M.; CHLUP, Z.

Released

1. 10. 2017

Publisher

ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND

Location

Oxford

ISBN

0272-8842

Periodical

Ceramics International

Year of study

43

Number

14

State

United Kingdom of Great Britain and Northern Ireland

Pages from

11265

Pages to

11273

Pages count

9

URL

http://www.sciencedirect.com/science/journal/02728842?sdc=1

BibTex

@article{BUT138350,
  author="Martin {Trunec} and Zdeněk {Chlup}",
  title="Subtractive manufacturing of customized hydroxyapatite scaffolds for bone
regeneration",
  journal="Ceramics International",
  year="2017",
  volume="43",
  number="14",
  pages="11265--11273",
  doi="10.1016/j.ceramint.2017.05.177",
  issn="0272-8842",
  url="http://www.sciencedirect.com/science/journal/02728842?sdc=1"
}