Publication detail

Preparation of biocompatible and bioresorbable fibrous structures

JINDROVA, E. NEMČOVSKÝ, J. ČÁSTKOVÁ, K.

Original Title

Preparation of biocompatible and bioresorbable fibrous structures

Type

abstract

Language

English

Original Abstract

Treatment of large wounds is often connected with replacement of the damaged tissue. The tissue can be substituted by a living tissue of the same kind or by an artificial materials. Nowadays, for example bones and joints are still replaced by metal implants. Beside the risk of an autoimmune reaction, there is also a problem with different mechanical properties of the implant and the natural body tissue. Therefore, new materials and technologies, which could enable production of bioresorbable implants, are searched. Because of the natural structure of the tissues, fiber materials are very promising. A very suitable process for production of fiber materials is electrospinning. Electrospinning enables preparation of nano- or microfibers of different materials and various morphologies using electrostatic voltage. Natural (e.g. collagen) or artificial (e.g. polycaprolactone, chitosan) polymers are suitable materials for soft tissues replacements. As hard tissues implants can be used Ca-P materials such as hydroxyapatite or β-tricalcium phosphate. Polymer-calcium phosphate composites were prepared in our laboratory using the electrospinning method. The aim was the preparation of a structure suitable for healing of smaller bone defects. The role of the polymer component (fibers) is to anchor the ceramic particles in the structure and to support the proliferation of the implant. The ceramic particles should enhance the mechanical properties of the implant and support bone tissue growth (ossification) of the structure. Structures composing only from ceramic (calcium phosphate) fibers were prepared, too. Preparation of these structures requires more precise preparation of the precursors, control of the spinning parameters and following thermal treatment. These fibers should have better mechanical toughness than the composite structure, the disadvantage is their brittleness which makes worse the manipulation with the samples. Better ossification and in-growing into the living tissue of this structure is expected. Cytotoxicity tests were provided on both kinds of samples. The influence of the composition and morphology of the fiber structure on the cell growth was assessed.

Keywords

Biomaterials, fibers, nanofibers, composites, hydroxyapatite, polycaprolactone, cytotoxicity

Authors

JINDROVA, E.; NEMČOVSKÝ, J.; ČÁSTKOVÁ, K.

Released

18. 10. 2017

Publisher

FUTURA, Petrovaradin, Serbia

Location

University of Novi Sad, Serbia

ISBN

978-86-6253-082- 0

Book

12th CONFERENCE for YOUNG SCIENTISTS in CERAMICS, PROGRAMME and BOOK OF ABSTRACTS

Edition

1

Edition number

1

Pages from

48

Pages to

49

Pages count

150

URL

http://www.tf.uns.ac.rs/cysc/Content/pdf/Book_of_Abstracts.pdf

BibTex

@misc{BUT144620,
  author="Eva {Jindrova} and Jakub {Nemčovský} and Klára {Částková}",
  title="Preparation of biocompatible and bioresorbable fibrous structures",
  booktitle="12th CONFERENCE for YOUNG SCIENTISTS in CERAMICS, PROGRAMME and BOOK OF ABSTRACTS",
  year="2017",
  series="1",
  edition="1",
  pages="48--49",
  publisher="FUTURA, Petrovaradin, Serbia",
  address="University of Novi Sad, Serbia",
  isbn="978-86-6253-082- 0",
  url="http://www.tf.uns.ac.rs/cysc/Content/pdf/Book_of_Abstracts.pdf",
  note="abstract"
}