Publication detail

Network Analysis of Proteins Associated with Schizophrenia

MUSILOVÁ, J. KOŠČOVÁ, P.

Original Title

Network Analysis of Proteins Associated with Schizophrenia

English Title

Network Analysis of Proteins Associated with Schizophrenia

Type

conference paper

Language

Czech

Original Abstract

The aim of this study is a network analysis of proteins ADRA1A, DRD1, DRD2 and HTR2A associated with a schizophrenia disease. By random graph analysis, all researched proteins were evaluated as significant. Using Cytoscape software, significant DPI (drug-protein interactions), PPI (protein-protein interactions) and pathways were revealed. By historeceptomics analysis, significant regions in amygdala, smooth muscle or spinal cord and prefrontal cortex were identified. The acquired knowledge can contribute to further research in the development of multitarget drugs against schizophrenia disease.

English abstract

The aim of this study is a network analysis of proteins ADRA1A, DRD1, DRD2 and HTR2A associated with a schizophrenia disease. By random graph analysis, all researched proteins were evaluated as significant. Using Cytoscape software, significant DPI (drug-protein interactions), PPI (protein-protein interactions) and pathways were revealed. By historeceptomics analysis, significant regions in amygdala, smooth muscle or spinal cord and prefrontal cortex were identified. The acquired knowledge can contribute to further research in the development of multitarget drugs against schizophrenia disease.

Keywords

Network Analysis, PPI, Schizophrenia

Key words in English

Network Analysis, PPI, Schizophrenia

Authors

MUSILOVÁ, J.; KOŠČOVÁ, P.

Released

26. 4. 2018

Location

Brno

ISBN

978-80-214-5614-3

Book

Proceedings of the 24rd Conference STUDENT EEICT 2018

Pages from

273

Pages to

275

Pages count

3

BibTex

@inproceedings{BUT147250,
  author="Jana {Musilová} and Pavlína {Cicková}",
  title="Network Analysis of Proteins Associated with Schizophrenia",
  booktitle="Proceedings of the 24rd Conference STUDENT EEICT 2018",
  year="2018",
  pages="273--275",
  address="Brno",
  isbn="978-80-214-5614-3"
}