Publication detail

Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility

BUCHTELOVÁ, H. STRMISKA, V. DOSTÁLOVÁ, S. MICHÁLEK, P. KŘÍŽKOVÁ, S. KOPEL, P. HYNEK, D. RICHTERA, L. ADAM, V. HEGER, Z.

Original Title

Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility

Type

conference paper

Language

English

Original Abstract

The current study demonstrates design preparation and characterization of biocompatible hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP) and polyoxyethylene stearate (POES). The resulting RuNPs were loaded with doxorubicin, as model anticancer drug. Resulting complex has an exceptional stability in physiological conditions. The cytotoxic effects of the complex were tested using cell lines representing breast and ovarian cancers and neuroblastoma. Although bare RuNPs had only negligible cytotoxicity, RuPDox caused an enhancement of doxorubicin cytotoxicity when compared to free doxorubicin. RuPDox promoted significantly increased stability of doxorubicin in human plasma and pronounced hemocompatibility assayed on human red blood cells. Results demonstrate that biocompatible RuNPs could have a great potential as versatile nanoplatform to enhance efficiency of anticancer therapy.

Keywords

Biocompatibility; nanomedicine; polyvinylpyrrolidone; polyoxyethylene stearate

Authors

BUCHTELOVÁ, H.; STRMISKA, V.; DOSTÁLOVÁ, S.; MICHÁLEK, P.; KŘÍŽKOVÁ, S.; KOPEL, P.; HYNEK, D.; RICHTERA, L.; ADAM, V.; HEGER, Z.

Released

31. 12. 2017

Publisher

Mendel University in Brno

ISBN

978-80-7509-529-9

Book

MendelNet 2017

Pages from

837

Pages to

842

Pages count

6

URL

https://mendelnet.cz/artkey/mnt-201701-0092_Ruthenium-based-core-shell-nanoparticles-with-exceptional-in-vitro-biocompatibility.php?back=/magno/mnt/2017/mn1.php?secid=4

Full text in the Digital Library

http://hdl.handle.net/11012/84172

BibTex

@inproceedings{BUT148707,
  author="Hana {Michálková} and Vladislav {Strmiska} and Simona {Dostálová} and Petr {Michálek} and Soňa {Křížková} and Pavel {Kopel} and David {Hynek} and Lukáš {Richtera} and Vojtěch {Adam} and Zbyněk {Heger}",
  title="Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility",
  booktitle="MendelNet 2017",
  year="2017",
  pages="837--842",
  publisher="Mendel University in Brno",
  isbn="978-80-7509-529-9",
  url="https://mendelnet.cz/artkey/mnt-201701-0092_Ruthenium-based-core-shell-nanoparticles-with-exceptional-in-vitro-biocompatibility.php?back=/magno/mnt/2017/mn1.php?secid=4"
}