Publication detail

Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart

OLEJNÍČKOVÁ, V. JANOUŠEK, O. RONZHINA, M. HEJČ, J. KVASILOVA, A. ZABRODSKA, E. SEDMERA, D.

Original Title

Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart

Type

conference paper

Language

English

Original Abstract

Syndromes of ventricular pre-excitation or atrio-ventricular (AV) re-entry are believed to results from inappropriate formation of AV junction (AVJ) during prenatal development. However, technical limitations have challenge to study foetal heart electrophysiology and are hampering the understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of rethrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during whole prenatal periods. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of AV electrical continuity was still detected in post-septated foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none APs were detected in prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling and spatiotemporally localise electrically active APs in the critical growing eriods.

Keywords

Optical mapping, action potential, di-4-ANEPPS, AV junction remodelling, foetal avian heart

Authors

OLEJNÍČKOVÁ, V.; JANOUŠEK, O.; RONZHINA, M.; HEJČ, J.; KVASILOVA, A.; ZABRODSKA, E.; SEDMERA, D.

Released

26. 9. 2018

Location

Maastricht

ISBN

2325-887X

Periodical

Computing in Cardiology

Year of study

45

Number

1

State

United States of America

Pages from

1

Pages to

4

Pages count

4

URL

https://ieeexplore.ieee.org/document/8744067

BibTex

@inproceedings{BUT151034,
  author="OLEJNÍČKOVÁ, V. and JANOUŠEK, O. and RONZHINA, M. and HEJČ, J. and KVASILOVA, A. and ZABRODSKA, E. and SEDMERA, D.",
  title="Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart",
  booktitle="Computing in Cardiology 2018",
  year="2018",
  journal="Computing in Cardiology",
  volume="45",
  number="1",
  pages="1--4",
  address="Maastricht",
  doi="10.22489/CinC.2018.055",
  issn="2325-887X",
  url="https://ieeexplore.ieee.org/document/8744067"
}