Publication detail

A Finite Element Bendo-Tensegrity Model of Eukaryotic Cell

BANSOD, Y. MATSUMOTO, T. NAGAYAMA, K. BURŠA, J.

Original Title

A Finite Element Bendo-Tensegrity Model of Eukaryotic Cell

Type

journal article in Web of Science

Language

English

Original Abstract

Mechanical interaction of cell with extracellular environment affects its function. The mechanisms by which mechanical stimuli are sensed and transduced into biochemical responses are still not well understood. Considering this, two finite element (FE) bendo-tensegrity models of a cell in different states are proposed with the aim to characterize cell deformation under different mechanical loading conditions: a suspended cell model elucidating the global response of cell in tensile test simulation and an adherent cell model explicating its local response in atomic force microscopy (AFM) indentation simulation. The force-elongation curve obtained from tensile test simulation lies within the range of experimentally obtained characteristics of smooth muscle cells (SMCs) and illustrates a nonlinear increase in reaction force with cell stretching. The force-indentation curves obtained from indentation simulations lie within the range of experimentally obtained curves of embryonic stem cells (ESCs) and exhibit the influence of indentation site on the overall reaction force of cell. Simulation results have demonstrated that actin filaments (AFs) and microtubules (MTs) play a crucial role in the cell stiffness during stretching, whereas actin cortex (AC) along with actin bundles (ABs) and MTs are essential for the cell rigidity during indentation. The proposed models quantify the mechanical contribution of individual cytoskeletal components to cell mechanics and the deformation of nucleus under different mechanical loading conditions. These results can aid in better understanding of structure-function relationships in living cells.

Keywords

cytoskeleton; finite element modeling; bendo-tensegrity; mechanotransduction

Authors

BANSOD, Y.; MATSUMOTO, T.; NAGAYAMA, K.; BURŠA, J.

Released

1. 10. 2018

Publisher

American Society of Mechanical Engineers

Location

USA

ISBN

0148-0731

Periodical

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Year of study

140

Number

10

State

United States of America

Pages from

1

Pages to

9

Pages count

9

URL

http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleid=2681670

BibTex

@article{BUT152146,
  author="BANSOD, Y. and MATSUMOTO, T. and NAGAYAMA, K. and BURŠA, J.",
  title="A Finite Element Bendo-Tensegrity Model of Eukaryotic Cell",
  journal="JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME",
  year="2018",
  volume="140",
  number="10",
  pages="1--9",
  doi="10.1115/1.4040246",
  issn="0148-0731",
  url="http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleid=2681670"
}