Publication detail

The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects

FARKAS, Á. LÍZAL, F. JEDELSKÝ, J. ELCNER, J. KARAS, J. BĚLKA, M. MIŠÍK, O. JÍCHA, M.

Original Title

The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects

Type

journal article in Web of Science

Language

English

Original Abstract

Quantification of airway deposition of aerosol particles is essential for the assessment of health risks of detrimental particles. Knowledge of deposition distribution is important also in the case of treatment with aerosolised drugs. It is also worth considering that deposition of inhaled particles in severe asthmatics can be different from the deposition in healthy subjects due to the modified breathing parameters, airway geometry and lobar flow distribution. The aim of this study was to apply combined experimental and numerical techniques to quantify the upper airway and bronchial deposition of the inhaled microparticles in healthy individuals in comparison with asthma patients. Idealised and realistic physical and digital replicas of the human airways were constructed. Deposition fractions and efficiencies of inhaled polydisperse mannitol and chitosan particles in different airway sections were measured and calculated. Deposition fraction of polydisperse mannitol particles in the idealised airway geometry assuming breathing conditions of healthy subjects was 21.9% and 18.3% when determined experimentally and by numerical simulations, respectively. Experimental measurements of deposition fraction of chitosan particles in the same geometry, but assuming breathing parameters characteristic of severe asthmatics yielded 32%, while simulations provided 30.1% for the same conditions. Extrathoracic deposition fraction of mannitol particles in healthy subjects measured in the realistic geometry was 71.1%, while bronchial deposition fraction was 5.3%. The corresponding simulations yielded 76.2% and 8.9% deposition fractions in the upper and bronchial airways, respectively. There was a good agreement between the experimental and simulation deposition results also in the different predefined sections of the airways. Present pilot study proved that lobar flow redistribution due to severe asthma significantly modified the deposition distribution of micro-particles. Although the present results refer only to small groups of healthy and asthmatic individuals, it clearly demonstrates the capability of carefully validated models to simulate the deposition of micron-size particles in larger populations of both groups.

Keywords

AEROSOL DEPOSITION; HUMAN AIRWAYS; LUNG-FUNCTION; FLOW

Authors

FARKAS, Á.; LÍZAL, F.; JEDELSKÝ, J.; ELCNER, J.; KARAS, J.; BĚLKA, M.; MIŠÍK, O.; JÍCHA, M.

Released

10. 7. 2020

Publisher

Elsevier

Location

OXFORD

ISBN

0021-8502

Periodical

JOURNAL OF AEROSOL SCIENCE

Year of study

147

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

16

Pages count

16

URL

https://www.sciencedirect.com/science/article/pii/S0021850220300719?via%3Dihub

Full text in the Digital Library

http://hdl.handle.net/11012/191378

BibTex

@article{BUT164472,
  author="Árpád {Farkas} and František {Lízal} and Jan {Jedelský} and Jakub {Elcner} and Jakub {Karas} and Miloslav {Bělka} and Ondrej {Mišík} and Miroslav {Jícha}",
  title="The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects",
  journal="JOURNAL OF AEROSOL SCIENCE",
  year="2020",
  volume="147",
  number="1",
  pages="1--16",
  doi="10.1016/j.jaerosci.2020.105582",
  issn="0021-8502",
  url="https://www.sciencedirect.com/science/article/pii/S0021850220300719?via%3Dihub"
}