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MUSILOVÁ, J. SEDLÁŘ, K.
Original Title
Tools for Time-Course Simulation in Systems Biology: A Brief Overview
Type
journal article in Web of Science
Language
English
Original Abstract
Dynamic modeling of biological systems is essential for understanding all properties of a given organism as it allows us to look not only at the static picture of an organism but also at its behavior under various conditions. With the increasing amount of experimental data, the number of tools that enable dynamic analysis also grows. However, various tools are based on different approaches, use different types of data, and offer different functions for analyses, so it can be difficult to choose the most suitable tool for a selected type of model. Here, we bring a brief overview containing descriptions of 50 tools for the reconstruction of biological models, their time-course simulation, and dynamic analysis. We examined each tool using test data and divided them based on the qualitative and quantitative nature of the mathematical apparatus they use.
Keywords
dynamic model; biological networks; qualitative; quantitative; hybrid
Authors
MUSILOVÁ, J.; SEDLÁŘ, K.
Released
11. 1. 2021
ISBN
1477-4054
Periodical
Briefings in Bioinformatics
Year of study
22
Number
5
State
United Kingdom of Great Britain and Northern Ireland
Pages from
1
Pages to
15
Pages count
URL
https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa392/6076933?guestAccessKey=ad7949aa-346e-421c-a28d-669d5874a590
BibTex
@article{BUT166211, author="Jana {Musilová} and Karel {Sedlář}", title="Tools for Time-Course Simulation in Systems Biology: A Brief Overview", journal="Briefings in Bioinformatics", year="2021", volume="22", number="5", pages="1--15", doi="10.1093/bib/bbaa392", issn="1477-4054", url="https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa392/6076933?guestAccessKey=ad7949aa-346e-421c-a28d-669d5874a590" }