Publication detail

CYTOTOXIC AND GENOTOXIC EFFECTS OF LIPOSOME PARTICLES WITH ENCAPSULATED NATURAL EXTRACTS

BOKROVÁ, J. RUČKOVÁ, M. MATOUŠKOVÁ, P. PAVELKOVÁ, R. HOOVÁ, J. MÁROVÁ, I.

Original Title

CYTOTOXIC AND GENOTOXIC EFFECTS OF LIPOSOME PARTICLES WITH ENCAPSULATED NATURAL EXTRACTS

Type

conference paper

Language

English

Original Abstract

Easy scale up of production led to an increase in cosmetic industry interest in lipid nanostructures. There are currently some liposome formulations on the market and the amount of these products will indoubtedly continue to grow. For this, detailed studies about their potential genotoxicity and cytotoxicity are neccesary. Presented work deals with preparation and characterization of liposome particles with aqueous and oil extracts of plant origin. The aim of this work was to observe cytotoxic and genotoxic effects of prepared liposomes. Total phenolics, flavonoids and antioxidant activity of plant extracts were determined using spectrophotometry as well as encapsulation efficiency. Stability of liposome particles was evaluated using zeta potential and size of liposomes was determined by dynamic light scattering. Potential genotoxic effects of liposomes were analysed using SOS Chromotest. Cytotoxicity of liposome particles was observed in human epidermal keratinocytes HEK (102-05a). Micro- and nanoparticles with encapsulated antioxidant and antimicrobial active compounds can enhance the effectiveness of cosmetics and pharmaceuticals. In this work, the potential use of liposome particles with natural plant extracts in appropriate concentration was proposed.

Keywords

Liposome; cosmetics; cytotoxicity; genotoxicity; antioxidant

Authors

BOKROVÁ, J.; RUČKOVÁ, M.; MATOUŠKOVÁ, P.; PAVELKOVÁ, R.; HOOVÁ, J.; MÁROVÁ, I.

Released

30. 3. 2018

Publisher

Tanger, a.s.

Location

TANGER LTD, KELTICKOVA 62, SLEZSKA, OSTRAVA 710 00, CZECH REPUBLIC

ISBN

978-80-87294-89-5

Book

Proceedings Paper, 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2018 (R))

Edition

1

Edition number

1

Pages from

739

Pages to

744

Pages count

6

BibTex

@inproceedings{BUT170297,
  author="Jitka {Bokrová} and Michaela {Ručková} and Petra {Skoumalová} and Renata {Uhlířová} and Julie {Hoová} and Ivana {Márová}",
  title="CYTOTOXIC AND GENOTOXIC EFFECTS OF LIPOSOME PARTICLES WITH ENCAPSULATED NATURAL EXTRACTS",
  booktitle="Proceedings Paper, 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2018 (R))",
  year="2018",
  series="1",
  number="1",
  pages="739--744",
  publisher="Tanger, a.s.",
  address="TANGER LTD, KELTICKOVA 62, SLEZSKA, OSTRAVA 710 00, CZECH REPUBLIC",
  isbn="978-80-87294-89-5"
}