Publication detail

Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

MASARYK, L. KOCZURKIEWICZ-ADAMCYZK, P. MILDE, D. NEMEC, I. SLOCZYNSKA, K. PEKALA, E. ŠTARHA, P.

Original Title

Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Type

journal article in Web of Science

Language

English

Original Abstract

Three dinuclear half-sandwich iridium(III) complexes [Ir-2(mu-L1)(eta(5)-Cp*)(2)Cl-2](PF6)2 (1), [Ir-2(mu-L2)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (2) and [Ir-2(mu-L3)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3) with tetradentate 4,4'-methylenedianiline-based N-donor ligands (L1-L3) were prepared and characterized by NMR spectroscopy, elemental analysis, mass spectrometry and FTIR spectroscopy. Complex 3 was hydrolytically less stable in 20% DMSO-d(6)/80% D2O than 1 and 2, while all the studied complexes were stable in the same mixture of solvents in the presence of PBS (pH 7.4). In addition, complexes 1-3 converted coenzyme NADH to its oxidized form (NAD(+)). Cytotoxicity of 1-3 was evaluated on five human cancer cell lines, in particular lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). The best-performing complex 2 showed comparable cytotoxicity to conventional cisplatin against the A549 and HepG2 cell lines. (C) 2021 Elsevier B.V. All rights reserved.

Keywords

Iridium; Half-sandwich; Dinuclear; 4,4 '-methylenedianiline; Cytotoxicity; Solution behaviour

Authors

MASARYK, L.; KOCZURKIEWICZ-ADAMCYZK, P.; MILDE, D.; NEMEC, I.; SLOCZYNSKA, K.; PEKALA, E.; ŠTARHA, P.

Released

15. 4. 2021

Publisher

ELSEVIER SCIENCE SA

Location

LAUSANNE

ISBN

0022-328X

Periodical

JOURNAL OF ORGANOMETALLIC CHEMISTRY

Year of study

938

State

Swiss Confederation

Pages from

121748

Pages to

121755

Pages count

7

URL

https://www.sciencedirect.com/science/article/pii/S0022328X21000693?via%3Dihub

BibTex

@article{BUT171182,
  author="Lukáš {Masaryk} and Paulina {Koczurkiewicz-Adamcyzk} and David {Milde} and Ivan {Nemec} and Karolina {Sloczynska} and Elzbieta {Pekala} and Pavel {Štarha}",
  title="Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity",
  journal="JOURNAL OF ORGANOMETALLIC CHEMISTRY",
  year="2021",
  volume="938",
  number="0",
  pages="121748--121755",
  doi="10.1016/j.jorganchem.2021.121748",
  issn="0022-328X",
  url="https://www.sciencedirect.com/science/article/pii/S0022328X21000693?via%3Dihub"
}