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PAŠTĚKA, R. SANTOS, P. BARROS, N. KOLÁŘ, R. FORJAN, M.
Original Title
Patient-Ventilator Interaction Testing Using the Electromechanical Lung Simulator xPULM (TM) during V/A-C and PSV Ventilation Mode
Type
journal article in Web of Science
Language
English
Original Abstract
During mechanical ventilation, a disparity between flow, pressure and volume demands of the patient and the assistance delivered by the mechanical ventilator often occurs. This paper introduces an alternative approach of simulating and evaluating patient-ventilator interactions with high fidelity using the electromechanical lung simulator xPULM (TM). The xPULM (TM) approximates respiratory activities of a patient during alternating phases of spontaneous breathing and apnea intervals while connected to a mechanical ventilator. Focusing on different triggering events, volume assist-control (V/A-C) and pressure support ventilation (PSV) modes were chosen to test patient-ventilator interactions. In V/A-C mode, a double-triggering was detected every third breathing cycle, leading to an asynchrony index of 16.67%, which is classified as severe. This asynchrony causes a significant increase of peak inspiratory pressure (7.96 +/- 6.38 vs. 11.09 +/- 0.49 cmH(2)O, p < 0.01)) and peak expiratory flow (-25.57 +/- 8.93 vs. 32.90 +/- 0.54 L/min, p < 0.01) when compared to synchronous phases of the breathing simulation. Additionally, events of premature cycling were observed during PSV mode. In this mode, the peak delivered volume during simulated spontaneous breathing phases increased significantly (917.09 +/- 45.74 vs. 468.40 +/- 31.79 mL, p < 0.01) compared to apnea phases. Various dynamic clinical situations can be approximated using this approach and thereby could help to identify undesired patient-ventilation interactions in the future. Rapidly manufactured ventilator systems could also be tested using this approach.
Keywords
biomedical engineering; breathing simulation; electromechanical lung simulator; patient– ventilator interactions; rapidly manufactured ventilator systems testing
Authors
PAŠTĚKA, R.; SANTOS, P.; BARROS, N.; KOLÁŘ, R.; FORJAN, M.
Released
21. 4. 2021
Publisher
MDPI
Location
BASEL
ISBN
2076-3417
Periodical
Applied Sciences - Basel
Year of study
11
Number
9
State
Swiss Confederation
Pages from
1
Pages to
14
Pages count
URL
https://www.mdpi.com/2076-3417/11/9/3745
Full text in the Digital Library
http://hdl.handle.net/11012/201666
BibTex
@article{BUT172367, author="Richard {Paštěka} and Pedro {Santos} and Nelson {Barros} and Radim {Kolář} and Mathias {Forjan}", title="Patient-Ventilator Interaction Testing Using the Electromechanical Lung Simulator xPULM (TM) during V/A-C and PSV Ventilation Mode", journal="Applied Sciences - Basel", year="2021", volume="11", number="9", pages="1--14", doi="10.3390/app11093745", issn="2076-3417", url="https://www.mdpi.com/2076-3417/11/9/3745" }