Publication detail

Lumbar Interbody Fusion Conducted on a Porcine Model with a Bioresorbable Ceramic/Biopolymer Hybrid Implant Enriched with Hyperstable Fibroblast Growth Factor 2

KRTIČKA, M. PLÁNKA, L. VOJTOVÁ, L. NEKUDA, V. ŠŤASTNÝ, P. SEDLÁČEK, R. BŘÍNEK, A. KAVKOVÁ, M. GÖPFERT, E. HEDVIČÁKOVÁ, V. RAMPICHOVÁ, M. KŘEN, L. LIŠKOVÁ, K. IRA, D. DORAZILOVÁ, J. SUCHÝ, T. ZIKMUND, T. KAISER, J. STARÝ, D. FALDYNA, M. TRUNEC, M.

Original Title

Lumbar Interbody Fusion Conducted on a Porcine Model with a Bioresorbable Ceramic/Biopolymer Hybrid Implant Enriched with Hyperstable Fibroblast Growth Factor 2

Type

journal article in Web of Science

Language

English

Original Abstract

An experimental animal study was designed to investigate the intervertebral fusion efficiency and safety of a bioresorbable ceramic/biopolymer hybrid implant enriched with FGF2-STAB(R) in comparison with a tricortical bone autograft used as a gold standard. Twenty-four experimental pigs underwent L2/3 discectomy with implantation of either the tricortical iliac crest bone autograft or the bioresorbable hybrid implant (BHI) followed by lateral intervertebral fixation. The quality of spinal fusion was assessed by micro-computed tomography (micro-CT), biomechanical testing, and histological examination at both 8 and 16 weeks after the surgery.

Keywords

micro-CT, biomechanics, histology, animal model, lumbar spinal fusion, tissue engineering, autograft, ceramic, collagen, FGF2

Authors

KRTIČKA, M.; PLÁNKA, L.; VOJTOVÁ, L.; NEKUDA, V.; ŠŤASTNÝ, P.; SEDLÁČEK, R.; BŘÍNEK, A.; KAVKOVÁ, M.; GÖPFERT, E.; HEDVIČÁKOVÁ, V.; RAMPICHOVÁ, M.; KŘEN, L.; LIŠKOVÁ, K.; IRA, D.; DORAZILOVÁ, J.; SUCHÝ, T.; ZIKMUND, T.; KAISER, J.; STARÝ, D.; FALDYNA, M.; TRUNEC, M.

Released

25. 6. 2021

Publisher

MDPI

ISBN

2227-9059

Periodical

Biomedicines

Year of study

9

Number

7

State

Swiss Confederation

Pages from

733

Pages to

758

Pages count

25

URL

https://www.mdpi.com/2227-9059/9/7/733

Full text in the Digital Library

http://hdl.handle.net/11012/202260

BibTex

@article{BUT172841,
  author="Milan {Krtička} and Ladislav {Plánka} and Lucy {Vojtová} and Vladimír {Nekuda} and Přemysl {Šťastný} and Radek {Sedláček} and Adam {Břínek} and Michaela {Kavková} and Eduard {Göpfert} and Věra {Hedvičáková} and Michaela {Rampichová} and Leoš {Křen} and Květoslava {Lišková} and Daniel {Ira} and Jana {Matulová} and Tomáš {Suchý} and Tomáš {Zikmund} and Jozef {Kaiser} and David {Starý} and Martin {Faldyna} and Martin {Trunec}",
  title="Lumbar Interbody Fusion Conducted on a Porcine Model with a Bioresorbable Ceramic/Biopolymer Hybrid Implant Enriched with Hyperstable Fibroblast Growth Factor 2",
  journal="Biomedicines",
  year="2021",
  volume="9",
  number="7",
  pages="733--758",
  doi="10.3390/biomedicines9070733",
  issn="2227-9059",
  url="https://www.mdpi.com/2227-9059/9/7/733"
}