Publication detail

Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients

BRABENEC, L. KLOBUŠIAKOVÁ, P. MEKYSKA, J. REKTOROVÁ, I.

Original Title

Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients

Type

journal article in Web of Science

Language

English

Original Abstract

Introduction Impaired copy of intersecting pentagons from the Mini-Mental State Examination (MMSE), has been used to assess dementia in Parkinson's disease (PD). We used a digitizing tablet during the pentagon copying test (PCT) as a potential tool for evaluating early cognitive deficits in PD without major cognitive impairment. We also aimed to uncover the neural correlates of the identified parameters using whole-brain magnetic resonance imaging (MRI). Methods We enrolled 27 patients with PD without major cognitive impairment and 25 age-matched healthy controls (HC). We focused on drawing parameters using a digitizing tablet. Parameters with between-group differences were correlated with cognitive outcomes and were used as covariates in the whole-brain voxel-wise analysis using voxel-based morphometry; familywise error (FWE) threshold p < 0.001. Results PD patients differed from HC in attention domain z-scores (p < 0.0001). In terms of tablet parameters, the groups differed in Shannon entropy (horizontal in-air, p = 0.003), which quantifies the movements between two strokes. In PD, a correlation was found between the median of Shannon entropy (horizontal in-air) and attention z-scores (R = −0.55, p = 0.006). The VBM revealed an association between our drawing parameter of interest and gray matter (GM) volume variability in the right superior parietal lobe (SPL). Conclusion Using a digitizing tablet during the PCT, we identified a novel entropy-based parameter that differed between the nondemented PD and HC groups. This in-air parameter correlated with the level of attention and was linked to GM volume variability of the region engaged in spatial attention.

Keywords

Parkinson's disease; kinematic analysis; pentagon copying test; in-air movement; Shannon entropy

Authors

BRABENEC, L.; KLOBUŠIAKOVÁ, P.; MEKYSKA, J.; REKTOROVÁ, I.

Released

1. 1. 2022

Publisher

Elsevier

ISBN

1353-8020

Periodical

PARKINSONISM & RELATED DISORDERS

Year of study

94

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

45

Pages to

48

Pages count

4

URL

https://www.sciencedirect.com/science/article/pii/S1353802021004442

Full text in the Digital Library

http://hdl.handle.net/11012/203237

BibTex

@article{BUT175128,
  author="Luboš {Brabenec} and Patrícia {Klobušiaková} and Jiří {Mekyska} and Irena {Rektorová}",
  title="Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients",
  journal="PARKINSONISM & RELATED DISORDERS",
  year="2022",
  volume="94",
  number="1",
  pages="45--48",
  doi="10.1016/j.parkreldis.2021.11.037",
  issn="1353-8020",
  url="https://www.sciencedirect.com/science/article/pii/S1353802021004442"
}