Publication detail

Questions about the role of P3HT nanoparticles in retinal stimulation

PALANKER, D. GLOWACKI, E. GHEZZI, D.

Original Title

Questions about the role of P3HT nanoparticles in retinal stimulation

Type

journal article in Web of Science

Language

English

Original Abstract

Maya-Vetencourt et al.1 recently reported that poly[3-hexylthiophene] nanoparticles (P3HT NPs) injected in the subretinal space of the rat model of retinal dystrophy (the Royal College of Surgeons (RCS) model)) “mediate light-evoked stimulation of retinal neurons and persistently rescue visual function”. The article also reported that the light-evoked stimulation of retinal neurons is electrical in nature and is mediated by a capacitive coupling between the NPs and the cell membrane. To support these claims, the authors performed a series of experiments that demonstrated the P3HT NPs induced a cellular response in vitro, a retinal response ex vivo and rescue the visual functions in vivo. However, a number of inconsistencies throughout the article cast doubt on these results and their interpretation, as outlined below.

Keywords

P3HT nanoparticles; retinal stimulation

Authors

PALANKER, D.; GLOWACKI, E.; GHEZZI, D.

Released

23. 12. 2021

Publisher

NATURE PORTFOLIO

Location

BERLIN

ISBN

1748-3395

Periodical

Nature Nanotechnology (electronic)

Year of study

16

Number

12

State

United States of America

Pages from

1330

Pages to

1332

Pages count

3

URL

https://www.nature.com/articles/s41565-021-01044-6

BibTex

@article{BUT176436,
  author="Daniel {Palanker} and Eric Daniel {Glowacki} and Diego {Ghezzi}",
  title="Questions about the role of P3HT nanoparticles in retinal stimulation",
  journal="Nature Nanotechnology (electronic)",
  year="2021",
  volume="16",
  number="12",
  pages="1330--1332",
  doi="10.1038/s41565-021-01044-6",
  issn="1748-3395",
  url="https://www.nature.com/articles/s41565-021-01044-6"
}