Publication detail

Dna repair in head and neck tumor cells and possibilities of its monitoring to estimate individual tumor radioresistance and selection of optimal primary treatmen

HORÁKOVÁ, Z. GUMULEC, J. KOPEČNÁ, O. PAGÁČOVÁ, E. MASAŘÍK, M. BAČÍKOVÁ, A. FALKOVÁ, I. RAUDENSKÁ, M. VIČAR, T. BINKOVÁ, H. FALK, M.

Original Title

Dna repair in head and neck tumor cells and possibilities of its monitoring to estimate individual tumor radioresistance and selection of optimal primary treatmen

Type

journal article in Scopus

Language

English

Original Abstract

In order to maximize post-therapeutic quality of life, radio(chemo) therapy becomes preferred over surgery in head-and-neck tumor (HNT) treatment. However, the therapy selection is only based on the clinical experience and patient's preferences as the radiosensitivity markers remain unknown. New possibilities of deciding on the best primary therapy, moving us towards personalized medicine based on quantifiable biomarkers, have been opened by studies on DNA radiation damage and repair in individual patients’ tumors. Together with the importance of radiotherapy in HNT oncology, we discuss here our preliminary results revealing the existence of several HNT groups with respect to genome stability and repair ability of tumor cells after irradiation. Monitoring of the formation and disap-pearance of γH2AX/53BP1 foci in tumor cell primo-cultures derived from individual patients suggests that DNA repair capacity of the identified groups correlates with the tumor cell radiosensitivity. Our findings thus improve understanding of HNT biology; nevertheless, the relationship between the repair groups and in vivo response of tumors to radiotherapy must be further studied. Since most HNTs do not suffer from repair defects, although their viability varies after irradiation, pre-therapeutic tests covering the full spectrum of HNT radiosensitivity causes will require the use of a combination of mul-tiple, still undiscovered biomarkers.

Keywords

DNA damage and repair; Head and neck tumors; Primary therapy dilemma; Radioresistance predictive markers; Radiotherapy

Authors

HORÁKOVÁ, Z.; GUMULEC, J.; KOPEČNÁ, O.; PAGÁČOVÁ, E.; MASAŘÍK, M.; BAČÍKOVÁ, A.; FALKOVÁ, I.; RAUDENSKÁ, M.; VIČAR, T.; BINKOVÁ, H.; FALK, M.

Released

1. 12. 2020

Publisher

Ceskoslovenska Lekarska Spolecnost

Location

Praha

ISBN

0008-7335

Periodical

Časopis lékařů českých

Year of study

159

Number

7-8

State

Czech Republic

Pages from

268

Pages to

274

Pages count

7

URL

https://www.prolekare.cz/casopisy/casopis-lekaru-ceskych/2020-7-8-1/reparace-dna-v-bunkach-nadoru-hlavy-a-krku-a-moznosti-vyuziti-monitorovani-tohoto-procesu-pro-odhad-radiorezistence-jednotlivych-nadoru-a-vyber-optimalni-primarni-lecby-125505

BibTex

@article{BUT177391,
  author="Zuzana {Horáková} and Jaromír {Gumulec} and Olga {Kopečná} and Eva {Pagáčová} and Michal {Masařík} and Alena {Bačíková} and Iva {Falková} and Martina {Raudenská} and Tomáš {Vičar} and Hana {Binková} and Martin {Falk}",
  title="Dna repair in head and neck tumor cells and possibilities of its monitoring to estimate individual tumor radioresistance and selection of optimal primary treatmen",
  journal="Časopis lékařů českých",
  year="2020",
  volume="159",
  number="7-8",
  pages="268--274",
  issn="0008-7335",
  url="https://www.prolekare.cz/casopisy/casopis-lekaru-ceskych/2020-7-8-1/reparace-dna-v-bunkach-nadoru-hlavy-a-krku-a-moznosti-vyuziti-monitorovani-tohoto-procesu-pro-odhad-radiorezistence-jednotlivych-nadoru-a-vyber-optimalni-primarni-lecby-125505"
}