Publication detail

Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection

MUKHERJEE, S. BYTEŠNÍKOVÁ, Z. MARTIN, S. ŠVEC, P. RIDOŠKOVÁ, A. PEKÁRKOVÁ, J. SEGUIN, C. WEICKERT, J. MESADDEQ, N. MÉLY, Y. RICHTERA, L. ANTON, H. ADAM, V.

Original Title

Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection

Type

journal article in Web of Science

Language

English

Original Abstract

Graphene-based 2D nanomaterials exhibit unique physicochemical, electric, and optical properties that facilitate applications in a wide range of fields including material science, electronics, and biotechnology. Recent studies have shown that graphene oxide (GO) and reduced graphene oxide (rGO) exhibit antimicrobial effects on bacteria and viruses. While the bactericidal activity of graphene-based nanomaterials is related to mechanical and oxidative damage to bacterial membranes, their antiviral activity has been less explored. Currently available experimental data are limited and suggest mechanical disruption of viral particles prior to infection. In this study, the antiviral properties of reduced GO-based nanocomposites decorated with Ag nanoparticles (rGO-Ag) are evidenced against human immunodeficiency virus-1 pseudovirus used as an enveloped virus model. By combining biochemical and original single virus imaging approaches, it is shown that rGO-Ag induces peroxidation of pseudoviral lipid membrane and that consequent alteration of membrane properties leads to a reduction in cell entry. In addition, rGO-Ag is found to be efficiently internalized in the host cell leading to the elevated expression of pro-inflammatory cytokines. Altogether, the presented results shed new light on the mechanisms of rGO-Ag antiviral properties and confirm the high potential of graphene derivatives as an antimicrobial material for biomedical applications.

Keywords

antiviral activity; graphene oxide; human immunodeficiency virus-1; immune response; lipid peroxidation; silver nanoparticles

Authors

MUKHERJEE, S.; BYTEŠNÍKOVÁ, Z.; MARTIN, S.; ŠVEC, P.; RIDOŠKOVÁ, A.; PEKÁRKOVÁ, J.; SEGUIN, C.; WEICKERT, J.; MESADDEQ, N.; MÉLY, Y.; RICHTERA, L.; ANTON, H.; ADAM, V.

Released

1. 2. 2023

Publisher

WILEY

Location

HOBOKEN

ISBN

2196-7350

Periodical

Advanced Materials Interfaces

Year of study

10

Number

6

State

Federal Republic of Germany

Pages from

1

Pages to

15

Pages count

15

URL

https://onlinelibrary.wiley.com/doi/10.1002/admi.202201996

Full text in the Digital Library

http://hdl.handle.net/11012/213719

BibTex

@article{BUT182384,
  author="Soumajit {Mukherjee} and Zuzana {Bytešníková} and Sophie {Martin} and Pavel {Švec} and Andrea {Ridošková} and Jana {Pekárková} and Cendrine {Seguin} and Jean-Luc {Weickert} and Nadia {Mesaddeq} and Yves {Mély} and Lukáš {Richtera} and Halina {Anton} and Vojtěch {Adam}",
  title="Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection",
  journal="Advanced Materials Interfaces",
  year="2023",
  volume="10",
  number="6",
  pages="1--15",
  doi="10.1002/admi.202201996",
  issn="2196-7350",
  url="https://onlinelibrary.wiley.com/doi/10.1002/admi.202201996"
}