Publication detail

Thermoresistant Newcastle disease vaccine effectivelyprotects SPF, native, and commercial chickens inchallenge with virulent virus

ABDOSHAH, M. HASSANZADEH, M. MASOUDI, S. ASHTARI, A. YOUSEFI, A. PARTOVI NASR, M.

Original Title

Thermoresistant Newcastle disease vaccine effectivelyprotects SPF, native, and commercial chickens inchallenge with virulent virus

Type

journal article in Web of Science

Language

English

Original Abstract

Background: Due to the more stability and a better homogenecity in immune response, the use of thermoresistant vaccines in different chicken types has been increased. Objective: This study aimed to evaluate the efficacy of a newly developed Newcastle disease vaccine (ND.TR.IR ) originating from 1-2 strain in specific pathogen-free (SPF) and native and broiler chickens. Methods: Following determination of pathogenicity indices on the candidate seed, three efficacy examinations were conducted. In the first experiment, 120 1-day-old SPF chickens were randomly allocated to six groups and either vaccinated with ND.TR.IR via eye drop at 1, 7, and 21 days of age (V-1, V-7, and V-21), or considered as non-vaccinated control groups (C-1, C-7, and C-21). At 20th post-vaccination day, sera hemag-glutination inhibition (HI) antibody titres against ND virus (NDV) were measured and then the chickens were challenged by virulent NDV (vNDV). In the second and third experiments, the efficacy of ND.TR.IR vaccine was compared to routine vaccination program (B1 and LaSota) in native and broiler chickens that were vaccinated at 10 and 20 days of age, respectively. The HI antibody titres were measured on 10, 20, 30, and 40 days of age, and also challenge efficacy test with vNDV was conducted on 30 days of age. Results: The studied virus, as a vaccinal seed, complied with the pathogenicity indices of avirulent NDV and molecular identity of 1-2 strain. In the efficacy evaluation trials, the vaccinated chickens had higher HI antibody titres against NDV compared with their corresponding control chickens (p < 0.05). Results of the challenge tests indicated 95% and 100% protection against vNDV in native, SPF, and broiler-vaccinated chickens, respectively. Conclusions: The present findings indicated that administration of ND.TR.IR induced appropriate HI antibody titres against NDV in SPF, native, and broiler chickens associated with good protection in efficacy test.

Keywords

chicken, efficacy, Newcastle disease, thermoresistant, vaccine

Authors

ABDOSHAH, M.; HASSANZADEH, M.; MASOUDI, S.; ASHTARI, A.; YOUSEFI, A.; PARTOVI NASR, M.

Released

7. 3. 2023

Publisher

Wiley-VCH

ISBN

2053-1095

Periodical

Veterinary Medicine and Science

Year of study

8

Number

4

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1539

Pages to

1546

Pages count

7

URL

https://onlinelibrary.wiley.com/doi/10.1002/vms3.794

Full text in the Digital Library

http://hdl.handle.net/11012/213622

BibTex

@article{BUT183045,
  author="Mohammad {Abdoshah} and Mohammad {Hassanzadeh} and Shahin {Masoudi} and Abbas {Ashtari} and Alireza {Yousefi} and Minoo {Partovi Nasr}",
  title="Thermoresistant Newcastle disease vaccine effectivelyprotects SPF, native, and commercial chickens inchallenge with virulent virus",
  journal="Veterinary Medicine and Science",
  year="2023",
  volume="8",
  number="4",
  pages="1539--1546",
  doi="10.1002/vms3.794",
  issn="2053-1095",
  url="https://onlinelibrary.wiley.com/doi/10.1002/vms3.794"
}