Publication detail

Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics Approach

MOHAMMAD, T. CHOUDHURY, A. HABIB, I. ASRANI, P. MATHUR, Y. UMAIR, M. ANJUM, F. SHAFIE, A. YADAV, D. HASSAN, I.

Original Title

Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics Approach

Type

journal article in Web of Science

Language

English

Original Abstract

A continual rise in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection causing coronavirus disease (COVID-19) has become a global threat. The main problem comes when SARS-CoV-2 gets mutated with the rising infection and becomes more lethal for humankind than ever. Mutations in the structural proteins of SARS-CoV-2, i.e., the spike surface glycoprotein (S), envelope (E), membrane (M) and nucleocapsid (N), and replication machinery enzymes, i.e., main protease (M-pro) and RNA-dependent RNA polymerase (RdRp) creating more complexities towards pathogenesis and the available COVID-19 therapeutic strategies. This study analyzes how a minimal variation in these enzymes, especially in S protein at the genomic/proteomic level, affects pathogenesis. The structural variations are discussed in light of the failure of small molecule development in COVID-19 therapeutic strategies. We have performed in-depth sequence- and structure-based analyses of these proteins to get deeper insights into the mechanism of pathogenesis, structure-function relationships, and development of modern therapeutic approaches. Structural and functional consequences of the selected mutations on these proteins and their association with SARS-CoV-2 virulency and human health are discussed in detail in the light of our comparative genomics analysis.

Keywords

severe acute respiratory syndrome coronavirus-2; coronavirus disease 2019; single amino acid substitutions; SARS-CoV-2 mutations; SARS-CoV-2 pathogenesis

Authors

MOHAMMAD, T.; CHOUDHURY, A.; HABIB, I.; ASRANI, P.; MATHUR, Y.; UMAIR, M.; ANJUM, F.; SHAFIE, A.; YADAV, D.; HASSAN, I.

Released

31. 10. 2021

Publisher

FRONTIERS MEDIA SA

Location

LAUSANNE

ISBN

2235-2988

Periodical

Frontiers in cellular and infection microbiology

Year of study

11

State

unknown

Pages count

14

BibTex

@article{BUT183368,
  author="Taj {Mohammad} and Arunabh {Choudhury} and Insan {Habib} and Purva {Asrani} and Yash {Mathur} and Mohammad {Umair} and Farah {Anjum} and Alaa {Shafie} and Dharmendra {Yadav} and Imtaiyaz {Hassan}",
  title="Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics Approach",
  journal="Frontiers in cellular and infection microbiology",
  year="2021",
  volume="11",
  pages="14",
  doi="10.3389/fcimb.2021.765039",
  issn="2235-2988"
}