Publication detail

Comprehensive analysis of putrescine metabolism in A. thaliana using GWAS, genetic risk score, metabolic modelling and data mining

SCHWARZEROVÁ, J. BARTOŇ, V. WALTHER, D. WECKWERTH, W.

Original Title

Comprehensive analysis of putrescine metabolism in A. thaliana using GWAS, genetic risk score, metabolic modelling and data mining

Type

conference paper

Language

English

Original Abstract

Polyamines are known to be functionally involved in plant responses to stress conditions. Despite a large amount of physiological and genetic data, the mode of action of polyamines, especially putrescine, at the molecular level still remains unclear. An increasing number of studies point to a role of putrescine in stress defense of plants due to influencing the formation of reactive oxygen species (ROS) in cellular stress conditions. Moreover, putrescine has been found to modulate abscisic acid (ABA) biosynthesis at the transcriptional level in response to low temperature, revealing a novel mode of action of polyamines as regulators of hormone biosynthesis. This study presents a new holistic approach towards the analysis of putrescine metabolism using genome-wide association studies and the calculation of genetic risk scores extended by Boolean analysis in metabolites network as well as data mining from available databases and literature. It can lead to a better understanding of biological processes involved in adaptation of plants to environmental changes.

Keywords

Diversification, GWAS, Genetic Risk Score, The 1001 Genomes Project, Reactive Oxygen Species

Authors

SCHWARZEROVÁ, J.; BARTOŇ, V.; WALTHER, D.; WECKWERTH, W.

Released

25. 4. 2023

Publisher

Brno University of Technology, Faculty of Elektronic Engineering and Communication

Location

Brno

ISBN

978-80-214-6154-3

Book

Proceedings II of the 29th Conference STUDENT EEICT 2023 Selected Papers

Edition

1

Pages from

151

Pages to

155

Pages count

5

URL

https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2023_sbornik_2_v2.pdf

BibTex

@inproceedings{BUT183448,
  author="Jana {Schwarzerová} and Vojtěch {Bartoň} and Dirk {Walther} and Wolfram {Weckwerth}",
  title="Comprehensive analysis of putrescine metabolism in A. thaliana using GWAS, genetic risk score, metabolic modelling and data mining",
  booktitle="Proceedings II of the 29th Conference STUDENT EEICT 2023 Selected Papers",
  year="2023",
  series="1",
  pages="151--155",
  publisher="Brno University of Technology, Faculty of Elektronic Engineering and Communication",
  address="Brno",
  isbn="978-80-214-6154-3",
  url="https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2023_sbornik_2_v2.pdf"
}