Publication detail

Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study

MRAČKOVÁ, M. MAREČEK, R. MEKYSKA, J. KOŠŤÁLOVÁ, M. REKTOROVÁ, I.

Original Title

Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study

Type

journal article in Web of Science

Language

English

Original Abstract

Hypokinetic dysarthria (HD) is a difficult-to-treat symptom affecting quality of life in patients with Parkinson’s disease (PD). Levodopa may partially alleviate some symptoms of HD in PD, but the neural correlates of these effects are not fully understood. The aim of our study was to identify neural mechanisms by which levodopa affects articulation and prosody in patients with PD. Altogether 20 PD patients participated in a task fMRI study (overt sentence reading). Using a single dose of levodopa after an overnight withdrawal of dopaminergic medication, levodopa-induced BOLD signal changes within the articulatory pathway (in regions of interest; ROIs) were studied. We also correlated levodopa-induced BOLD signal changes with the changes in acoustic parameters of speech. We observed no significant changes in acoustic parameters due to acute levodopa administration. After levodopa administration as compared to the OFF dopaminergic condition, patients showed task-induced BOLD signal decreases in the left ventral thalamus (p = 0.0033). The changes in thalamic activation were associated with changes in pitch variation (R = 0.67, p = 0.006), while the changes in caudate nucleus activation were related to changes in the second formant variability which evaluates precise articulation (R = 0.70, p = 0.003). The results are in line with the notion that levodopa does not have a major impact on HD in PD, but it may induce neural changes within the basal ganglia circuitries that are related to changes in speech prosody and articulation.

Keywords

Parkinson’s disease; hypokinetic dysarthria; task fMRI; Levodopa

Authors

MRAČKOVÁ, M.; MAREČEK, R.; MEKYSKA, J.; KOŠŤÁLOVÁ, M.; REKTOROVÁ, I.

Released

9. 11. 2023

Publisher

SPRINGER WIEN

ISBN

0300-9564

Periodical

JOURNAL OF NEURAL TRANSMISSION

Year of study

1

Number

11

State

Republic of Austria

Pages from

1

Pages to

7

Pages count

7

URL

https://doi.org/10.1007/s00702-023-02715-5

BibTex

@article{BUT185267,
  author="MRAČKOVÁ, M. and MAREČEK, R. and MEKYSKA, J. and KOŠŤÁLOVÁ, M. and REKTOROVÁ, I.",
  title="Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study",
  journal="JOURNAL OF NEURAL TRANSMISSION",
  year="2023",
  volume="1",
  number="11",
  pages="7",
  doi="10.1007/s00702-023-02715-5",
  issn="0300-9564",
  url="https://doi.org/10.1007/s00702-023-02715-5"
}