Publication detail

Interaction of drugs with soil organic matter studied by microcalorimetry

KROUSKÁ, J. PAPKO, N. KLUČÁKOVÁ, M.

Original Title

Interaction of drugs with soil organic matter studied by microcalorimetry

Type

conference paper

Language

English

Original Abstract

The usage of pharmaceuticals increases worldwide every year. The residues of these substances are excreted by the human or animal bodies and thus come into direct contact with the environment, mainly soils and ground water. The accumulation of pharmaceuticals in natural ecosystems may be problematic in the future therefore the knowledge of their behaviour, transport and interactions in the ecosystems is essential for their treatment. The most reactive substances in soils are humic as well as fulvic substances. Two fulvic acids stand as the model reactants with different pharmaceuticals in this study. These reactive compounds contain several kinds of active functional groups, such as hydrophilic hydroxylic or carboxylic groups, and also diverse hydrophobic structures. The interactions between fulvic acids and solutions of pure drugs were studied by isothermal titration calorimetry. The aim of the study was to observe the heat effects of the interactions and to describe the intensity of the binding process.

Keywords

Humic substances, drug, interaction, microcalorimetry

Authors

KROUSKÁ, J.; PAPKO, N.; KLUČÁKOVÁ, M.

Released

23. 11. 2022

Location

Brno

ISBN

978-80-88365-09-9

Book

Proceedings 14th International Conference on Nanomaterials - Research & Application

Pages from

255

Pages to

259

Pages count

5

BibTex

@inproceedings{BUT187703,
  author="Jitka {Krouská} and Nadezhda {Papko} and Martina {Klučáková}",
  title="Interaction of drugs with soil organic matter studied by microcalorimetry",
  booktitle="Proceedings 14th International Conference on Nanomaterials - Research & Application",
  year="2022",
  pages="255--259",
  address="Brno",
  doi="10.37904/nanocon.2022.4615",
  isbn="978-80-88365-09-9"
}