Publication detail

Biomarker Profiling and Integrating Heterogeneous Models for Enhanced Multi-Grade Breast Cancer Prognostication

JOSHI, R. SRIVASTAVA, P. MISHRA, R. BURGET, R. DUTTA, M.

Original Title

Biomarker Profiling and Integrating Heterogeneous Models for Enhanced Multi-Grade Breast Cancer Prognostication

Type

journal article in Web of Science

Language

English

Original Abstract

Background Breast cancer remains a leading cause of female mortality worldwide, exacerbated by limited awareness, inadequate screening resources, and treatment options. Accurate and early diagnosis is crucial for improving survival rates and effective treatment. Objectives This study aims to develop an innovative artificial intelligence (AI) based model for predicting breast cancer and its various histopathological grades by integrating multiple biomarkers and subject age, thereby enhancing diagnostic accuracy and prognostication. Methods A novel ensemble-based machine learning (ML) framework has been introduced that integrates three distinct biomarkers—beta-human chorionic gonadotropin (β-hCG), Programmed Cell Death Ligand 1 (PD-L1), and alpha-fetoprotein (AFP)—alongside subject age. Hyperparameter optimization was performed using the Particle Swarm Optimization (PSO) algorithm, and minority oversampling techniques were employed to mitigate overfitting. The model's performance was validated through rigorous five-fold cross-validation. Results The proposed model demonstrated superior performance, achieving a 97.93% accuracy and a 98.06% F1-score on meticulously labeled test data across diverse age groups. Comparative analysis showed that the model outperforms state-of-the-art approaches, highlighting its robustness and generalizability. Conclusion By providing a comprehensive analysis of multiple biomarkers and effectively predicting tumor grades, this study offers a significant advancement in breast cancer screening, particularly in regions with limited medical resources. The proposed framework has the potential to reduce breast cancer mortality rates and improve early intervention and personalized treatment strategies.

Keywords

AI-Based Screening; Biomarker-Driven Classification; Breast Cancer Diagnosis; Ensemble Learning; Machine Learning in Healthcare;Multi-Grade Prediction

Authors

JOSHI, R.; SRIVASTAVA, P.; MISHRA, R.; BURGET, R.; DUTTA, M.

Released

1. 10. 2024

Publisher

Elsevier Ireland Ltd

ISBN

0169-2607

Periodical

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Year of study

255

Number

October 2024

State

Kingdom of the Netherlands

Pages from

1

Pages to

14

Pages count

14

URL

https://www.sciencedirect.com/science/article/abs/pii/S0169260722003789

BibTex

@article{BUT189152,
  author="Rakesh Chandra {Joshi} and Pallavi {Srivastava} and Rashmi {Mishra} and Radim {Burget} and Malay Kishore {Dutta}",
  title="Biomarker Profiling and Integrating Heterogeneous Models for Enhanced Multi-Grade Breast Cancer Prognostication",
  journal="COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE",
  year="2024",
  volume="255",
  number="October 2024",
  pages="1--14",
  doi="10.1016/j.cmpb.2024.108349",
  issn="0169-2607",
  url="https://www.sciencedirect.com/science/article/abs/pii/S0169260722003789"
}