Publication detail

Advanced Freeze-Dried Hydrogel Films for Combatting Bacterial Infections in Chronic Wounds

ČERNÁ, E. BRTNÍKOVÁ, J. LIPOVÝ, B. FOHLEROVÁ, Z. VACEK, L. VOJTOVÁ, L.

Original Title

Advanced Freeze-Dried Hydrogel Films for Combatting Bacterial Infections in Chronic Wounds

Type

abstract

Language

English

Original Abstract

Infected chronic wounds affected by antibiotic-resistant bacteria are a significant global healthcare problem, leading to prolonged patient suffering, increased healthcare costs, and morbidity rates, which demand innovative solutions. This work presents a novel approach using antiseptic-coated gum Karaya/PVA hydrogel films to combat resistant bacterial infections. The freeze-dried films integrate antimicrobial agent within a biocompatible matrix, offering sustained release and prolonged efficacy. The freeze-drying process facilitates the fabrication of the hydrogel films and enables crosslinking within the hydrogel matrix enhancing the mechanical strength and stability of the films, making them more resilient to physical stresses encountered during wound management. Key analyses include hydrogel degradation and mechanical strength, antimicrobial agent release, cytotoxicity, and antibacterial testing. These tests confirm the film's ability to absorb exudates, maintain stability in the hydrated state for up to 30 days, withstand physical stresses needed for easy handling, exhibit biocompatibility and sufficient antimicrobial activity to suppress and eliminate bacterial infection. In conclusion, this technology presents a promising strategy for managing infected chronic wounds, enhancing wound healing, and alleviating the global healthcare burden.

Keywords

Hydrogel, antibacterial, gum Karaya, PVA, antimicrobial agent hydrogel film

Authors

ČERNÁ, E.; BRTNÍKOVÁ, J.; LIPOVÝ, B.; FOHLEROVÁ, Z.; VACEK, L.; VOJTOVÁ, L.

Released

2. 7. 2024

Location

Greece, Thessaloniki

Pages from

152

Pages to

152

Pages count

1

URL

https://www.nanotexnology.com/index.php/abstract-books-2024/send/5-abstract-books-2024/16-nn24-abstract-book

BibTex

@misc{BUT189261,
  author="Eva {Černá} and Jana {Brtníková} and Břetislav {Lipový} and Zdenka {Fohlerová} and Lukáš {Vacek} and Lucy {Vojtová}",
  title="Advanced Freeze-Dried Hydrogel Films for Combatting Bacterial Infections in Chronic
Wounds",
  booktitle="21st International Conference on Nanosciences & Nanotechnologies, Book of Abstract, Greece, Thessaloniki, 2-5 July 2024",
  year="2024",
  pages="152--152",
  address="Greece, Thessaloniki",
  url="https://www.nanotexnology.com/index.php/abstract-books-2024/send/5-abstract-books-2024/16-nn24-abstract-book",
  note="abstract"
}