Publication detail

Assessing Lettuce Exposure to a Multi-Pharmaceutical Mixture in Soil: Insights from LC-ESI-TQ Analysis and the Impact of Biochar on Pharmaceutical Bioavailability

FUČÍK, J. JAŠEK, V. HAMPLOVÁ, M. NAVRKALOVÁ, J. ZLÁMALOVÁ GARGOŠOVÁ, H. MRAVCOVÁ, L.

Original Title

Assessing Lettuce Exposure to a Multi-Pharmaceutical Mixture in Soil: Insights from LC-ESI-TQ Analysis and the Impact of Biochar on Pharmaceutical Bioavailability

Type

journal article in Web of Science

Language

English

Original Abstract

Agricultural practices introduce pharmaceutical (PhAC) residues into the terrestrial environment, potentially endangering agricultural crops and human health. This study aimed to evaluate various aspects related to the presence of pharmaceuticals in the lettuce-soil system, including bioconcentration factors (BCFs), translocation factors (TFs), ecotoxicological effects, the influence of biochar on the PhAC bioavailability, persistence in soil, and associated environmental and health risks. Lettuce (Lactuca sativa L.) was exposed to a mixture of 25 PhACs in two scenarios: initially contaminated soil (ranging from 0 to 10,000 ng center dot g(-1)) and soil irrigated with contaminated water (ranging from 0 to 1000 mu g center dot L-1) over a 28-day period. The findings revealed a diverse range of BCFs (0.068-3.7) and TFs (0.032-0.58), indicating the uptake and translocation potential of pharmaceuticals by lettuce. Significant ecotoxicological effects on L. sativa, including weight change and increased mortality, were observed (p < 0.05). Interestingly, biochar did not significantly affect PhAC uptake by L. sativa (p > 0.05), while it significantly influenced the soil degradation kinetics of 12 PhACs (p < 0.05). Additionally, the estimated daily intake of PhACs through the consumption of L. sativa suggested negligible health risks, although concerns arose regarding the potential health risks if other vegetable sources were similarly contaminated with trace residues. Furthermore, this study evaluated the environmental risk associated with the emergence of antimicrobial resistance (AMR) in soil, as medium to high. In conclusion, these findings highlight the multifaceted challenges posed by pharmaceutical contamination in agricultural environments and emphasize the importance of proactive measures to mitigate the associated risks to both environmental and human health.

Keywords

pharmaceutical uptake; soil-lettuce system; liquid chromatography; mass spectrometry; ecotoxicology; estimated daily intake; emergence of antimicrobial resistance

Authors

FUČÍK, J.; JAŠEK, V.; HAMPLOVÁ, M.; NAVRKALOVÁ, J.; ZLÁMALOVÁ GARGOŠOVÁ, H.; MRAVCOVÁ, L.

Released

4. 9. 2024

Publisher

AMER CHEMICAL SOC

Location

WASHINGTON

ISBN

2470-1343

Periodical

ACS OMEGA

Year of study

9

Number

37

State

United States of America

Pages from

39065

Pages to

39081

Pages count

17

URL

https://pubs.acs.org/doi/10.1021/acsomega.4c05831

BibTex

@article{BUT189423,
  author="Jan {Fučík} and Vojtěch {Jašek} and Marie {Hamplová} and Jitka {Navrkalová} and Helena {Zlámalová Gargošová} and Ludmila {Mravcová}",
  title="Assessing Lettuce Exposure to a Multi-Pharmaceutical Mixture in Soil: Insights from LC-ESI-TQ Analysis and the Impact of Biochar on Pharmaceutical Bioavailability",
  journal="ACS OMEGA",
  year="2024",
  volume="9",
  number="37",
  pages="39065--39081",
  doi="10.1021/acsomega.4c05831",
  issn="2470-1343",
  url="https://pubs.acs.org/doi/10.1021/acsomega.4c05831"
}