Publication detail

An Investigation of Glutathione-Platinum(II) Interactions by Means of the Flow Injection Analysis Using Glassy Carbon Electrode

ZÍTKA, O. HÚSKA, D. KŘÍŽKOVÁ, S. ADAM, V. GRACE, C. TRNKOVÁ, L. HORNA, A. HUBÁLEK, J. KIZEK, R.

Original Title

An Investigation of Glutathione-Platinum(II) Interactions by Means of the Flow Injection Analysis Using Glassy Carbon Electrode

Type

journal article - other

Language

English

Original Abstract

Glutathione was discovered by M. J. de Rey Pailhade at the end of the 19th century as the substance (hydrogénant le soufre), which was renamed by F.G. Hopkins in 1921. Hopkins first characterised the compound as a dipeptide of glutamic acid and cysteine. Few years later he suggested the correct structure to be a tripeptide which also contains glycine. GSH as a ubiquitous tripeptide thiol is a vital intra- and extra-cellular protective antioxidant. It plays a number of key roles in the controlling of signalling processes, detoxifying of some xenobiotics and heavy metals etc. Glutathione is found almost exclusively in its reduced form; since the enzyme, which reverts it from its oxidized form (GSSG) called glutathione reductase, is constitutively active and inducible upon oxidative stress. In fact, the ratio of reduced to oxidized glutathione within cells is often used as a marker of cytotoxicity.

Keywords

Glutathione; Carbon paste electrode; Thiols; Cisplatin; Cancer; Flow injection analysis with electrochemical detection.

Authors

ZÍTKA, O.; HÚSKA, D.; KŘÍŽKOVÁ, S.; ADAM, V.; GRACE, C.; TRNKOVÁ, L.; HORNA, A.; HUBÁLEK, J.; KIZEK, R.

Released

20. 7. 2007

Publisher

MDPI

ISBN

1424-8220

Periodical

SENSORS

Year of study

7

Number

1

State

Swiss Confederation

Pages from

1256

Pages to

1270

Pages count

15

URL

http://www.mdpi.com/1424-8220/7/7/1256

Full text in the Digital Library

http://hdl.handle.net/11012/70085

BibTex

@article{BUT44510,
  author="ZÍTKA, O. and HÚSKA, D. and KŘÍŽKOVÁ, S. and ADAM, V. and GRACE, C. and TRNKOVÁ, L. and HORNA, A. and HUBÁLEK, J. and KIZEK, R.",
  title="An Investigation of Glutathione-Platinum(II) Interactions by Means of the Flow Injection Analysis Using Glassy Carbon Electrode",
  journal="SENSORS",
  year="2007",
  volume="7",
  number="1",
  pages="1256--1270",
  doi="10.3390/s7071256",
  issn="1424-8220",
  url="http://www.mdpi.com/1424-8220/7/7/1256"
}