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NEUŽIL, P., GISELBRECHT, S., LANGE, K., HUANG, TJ., MANZ, A.
Original Title
Revisiting lab-on-a-chip technology for drug discovery
Type
journal article in Web of Science
Language
English
Original Abstract
The field of microfluidics or lab-on-a-chip technology aims to improve and extend the possibilities of bioassays, cell biology and biomedical research based on the idea of miniaturization. Microfluidic systems allow more accurate modelling of physiological situations for both fundamental research and drug development, and enable systematic high-volume testing for various aspects of drug discovery. Microfluidic systems are in development that not only model biological environments but also physically mimic biological tissues and organs; such 'organs on a chip' could have an important role in expediting early stages of drug discovery and help reduce reliance on animal testing. This Review highlights the latest lab-on-a-chip technologies for drug discovery and discusses the potential for future developments in this field.
Keywords
HIGH-THROUGHPUT ANALYSIS; STEM-CELL NICHES; MICROFLUIDIC DEVICE; CAENORHABDITIS-ELEGANS; FEMTOLITER-VOLUME; PICOLITER-VOLUME; ANALYSIS SYSTEMS; MAMMALIAN-CELLS; SINGLE-CELLS; DROPLETS
Authors
RIV year
2012
Released
30. 8. 2012
Publisher
NATURE PUBLISHING GROUP,
Location
MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
ISBN
1474-1776
Periodical
NATURE REVIEWS DRUG DISCOVERY
Year of study
2012 (11)
Number
8
State
United Kingdom of Great Britain and Northern Ireland
Pages from
620
Pages to
632
Pages count
13
BibTex
@article{BUT98592, author="Pavel {Neužil}", title="Revisiting lab-on-a-chip technology for drug discovery", journal="NATURE REVIEWS DRUG DISCOVERY", year="2012", volume="2012 (11)", number="8", pages="620--632", doi="10.1038/nrd3799", issn="1474-1776" }