Publication detail

Revisiting lab-on-a-chip technology for drug discovery

NEUŽIL, P., GISELBRECHT, S., LANGE, K., HUANG, TJ., MANZ, A.

Original Title

Revisiting lab-on-a-chip technology for drug discovery

Type

journal article in Web of Science

Language

English

Original Abstract

The field of microfluidics or lab-on-a-chip technology aims to improve and extend the possibilities of bioassays, cell biology and biomedical research based on the idea of miniaturization. Microfluidic systems allow more accurate modelling of physiological situations for both fundamental research and drug development, and enable systematic high-volume testing for various aspects of drug discovery. Microfluidic systems are in development that not only model biological environments but also physically mimic biological tissues and organs; such 'organs on a chip' could have an important role in expediting early stages of drug discovery and help reduce reliance on animal testing. This Review highlights the latest lab-on-a-chip technologies for drug discovery and discusses the potential for future developments in this field.

Keywords

HIGH-THROUGHPUT ANALYSIS; STEM-CELL NICHES; MICROFLUIDIC DEVICE; CAENORHABDITIS-ELEGANS; FEMTOLITER-VOLUME; PICOLITER-VOLUME; ANALYSIS SYSTEMS; MAMMALIAN-CELLS; SINGLE-CELLS; DROPLETS

Authors

NEUŽIL, P., GISELBRECHT, S., LANGE, K., HUANG, TJ., MANZ, A.

RIV year

2012

Released

30. 8. 2012

Publisher

NATURE PUBLISHING GROUP,

Location

MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND

ISBN

1474-1776

Periodical

NATURE REVIEWS DRUG DISCOVERY

Year of study

2012 (11)

Number

8

State

United Kingdom of Great Britain and Northern Ireland

Pages from

620

Pages to

632

Pages count

13

BibTex

@article{BUT98592,
  author="Pavel {Neužil}",
  title="Revisiting lab-on-a-chip technology for drug discovery",
  journal="NATURE REVIEWS DRUG DISCOVERY",
  year="2012",
  volume="2012 (11)",
  number="8",
  pages="620--632",
  doi="10.1038/nrd3799",
  issn="1474-1776"
}