Publication detail

Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle from Wistar rats

SOCHOR, J. POHANKA, M. RUTTKAY-NEDECKÝ, B. ZÍTKA, O. HYNEK, D. MAREŠ, P. ZEMAN, L. ADAM, V. KIZEK, R.

Original Title

Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle from Wistar rats

Type

journal article in Web of Science

Language

English

Original Abstract

Selenium is a micronutrient, localized in the active sites of enzymes such as glutathione peroxidase and thioredoxin reductase, and participating together with these enzymes in an antioxidant defence system of organisms against free radicals. Administration of selenium is necessary for maintaining oxidative homeostasis. The present experiment is aimed at investigation of selenium impact on basal metabolic processes and selected antioxidants in a Wistar rat model, fed selenium in organic and inorganic forms. Liver, kidney, brain and muscle were sampled during a month-long feeding with four different doses of selenium (0.075 mg or 1.5 mg of inorganic and/or organic selenium per kg of feed). We found a significant reduction in glutathione level in liver tissue regardless of the form of the administered selenium. On the other hand, selenium caused a decreased glutathione reductase level in the liver and metallothionein level in the liver, kidney and muscle.

Keywords

Selenium; Oxidative Stress; Glutathione; Glutathione Reductase; Metallothionein

Authors

SOCHOR, J.; POHANKA, M.; RUTTKAY-NEDECKÝ, B.; ZÍTKA, O.; HYNEK, D.; MAREŠ, P.; ZEMAN, L.; ADAM, V.; KIZEK, R.

RIV year

2012

Released

1. 10. 2012

Publisher

VERSITA, SOLIPSKA 14A-1, 02-482

Location

WARSAW, POLAND

ISBN

1895-1066

Periodical

CENTRAL EUROPEAN JOURNAL OF CHEMISTRY

Year of study

10

Number

5

State

Republic of Poland

Pages from

1442

Pages to

1451

Pages count

9

BibTex

@article{BUT98607,
  author="SOCHOR, J. and POHANKA, M. and RUTTKAY-NEDECKÝ, B. and ZÍTKA, O. and HYNEK, D. and MAREŠ, P. and ZEMAN, L. and ADAM, V. and KIZEK, R.",
  title="Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle from Wistar rats",
  journal="CENTRAL EUROPEAN JOURNAL OF CHEMISTRY",
  year="2012",
  volume="10",
  number="5",
  pages="1442--1451",
  issn="1895-1066"
}