Course detail

Special Toxicology

FCH-MAO_STXAcad. year: 2011/2012

The science of Toxicology. Terminology of Toxicology. Principles of toxicology. The relation of dose - effect. Manifestations of molecular, cell and organ toxicity. Biotransformation of xenobiotics. Toxicology characteristics of elements, metals, inorganic and organic compounds. Environmental pollutants (oxides - sulphur, nitrogen, etc., ozone, nitrates, cyanides, PAH, PCB, dioxins, other pollutants into industrial production). Toxicology of industrial products and toxic pollutants (benzene, asbestos, and products of oil industry, etc.). Toxicological important compounds in food, toxicity in foods. Phytotoxicology, effets of fungal, plant, animal toxins. Carcinogenesis, mutagenesis, teratogenesis (molecular mechanism of processes, natural and synthetic mutagenic and carcinogenic agents). Radiotoxicology, chemical warfare agents. Product safety, International monitoring of hazardous groups of chemicals and materials. The classification of chemical compounds in CZ and EU, actual legislative.

Language of instruction

English

Number of ECTS credits

5

Mode of study

Not applicable.

Guarantor

Mgr. Helena Doležalová Weissmannová, Ph.D.

Department

Institute of Chemistry and Technology of Environmental Protection (ÚCHTOŽP)

Learning outcomes of the course unit

Knowledges in the field on Special toxicology - toxicology of elements, hazardous metals, inorganic, organic and complex compounds. Biotransformation of of Xenobiotics. Toxicity of Environmental Pollutants. Toxic agents, poison in food, nature. Carcinogenesis, mutagenesis, teratogenesis, Oxidative Stress. Product safety and actual legislative of chemicals.

Prerequisites

Principles of general toxicology, inorganic, organic chemistry, environmental chemistry, biochemistry.

Co-requisites

Not applicable.

Planned learning activities and teaching methods

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations.

Assesment methods and criteria linked to learning outcomes

Examination - written and oral parts.

Course curriculum

1. Introduction of Special Toxikology, Contents, Terminology, Principles (Exposure, Dose, Toxicity, Limits).
2. The interaction of toxic compounds wit organism. Manifestations of molecular, cell and organ toxicity.
3. Xenobiochemistry. The fate of chemical compounds in organism, pathways of toxic compounds and metabolites.
4. Toxicology of elements, hazardous metals, inorganic compounds, mechanism of interactions of metals in body. Metal transport and metabolism.
5. Toxicology organic and organometallic compounds.
6. Environmental pollutants. Industrial toxicology.
7. Effects of fungal and mushroom, plant, animal toxins on human body. Important toxins of microbes (bakteria, micromycota), fungi (edible, nonedible), plants, animals. Metabolites of plants, animals. Toxicological important micro and macromycetes.
8. Carcinogenesis, mutagenesis, teratogenesis (molecular mechanism of processes, inhibitors, inductors, natural and synthetic mutagenic and carcinogenic agents), Teratogenesis, teratogene.
9. Chemical warfare agents.
10. Product safety, International monitoring of hazardous groups of chemicals and materials. The classification of chemical compounds in CZ and EU, actual legislative of chemicals.

Work placements

Not applicable.

Aims

Getting deeper knowledges of toxicology of elements, hazardous metals, inorganic, organic and complex compounds. Biotransformation of of Xenobiotics. The enlargement of environmental pollutants, industrial toxicology. The presence of toxic agents, poison in food, nature. The elucidation of processes of Carcinogenesis, mutagenesis, teratogenesis, Oxidative Stress. Basic information of product safety and actual legislative of chemicals.

Specification of controlled education, way of implementation and compensation for absences

none

Recommended optional programme components

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

Hodgson, E., Levi P. E., A Textbook of Modern Toxicology, Elsevier Sci. Publ., New York, Amsterdam, London, 1987 (EN)
Timbrell, J. A., Introduction to Toxicology. Taylor and Francis, London, 1995; (EN)

Recommended reading

Marhold, J., Přehled průmyslové toxikologie, Anorganické látky.Organické látky, Avicenum, Praha 1980,1986 (EN)
Tichý, M., Toxikologie pro chemiky. Universita Karlova, Praha, 2002 (EN)

Classification of course in study plans

Type of course unit

 

Lecture

26 hod., optionally

Teacher / Lecturer

Mgr. Helena Doležalová Weissmannová, Ph.D.

Guided consultation in combined form of studies

26 hod., optionally

Teacher / Lecturer

Mgr. Helena Doležalová Weissmannová, Ph.D.