Course detail

Materials and Components for Biomedicine

FEKT-AMBMAcad. year: 2011/2012

The subject deals with special materials for biomedical practice, new electrochemical sources for special devices and facilities, e.g. cardiostimulators and defibrilators, the impact of the biological environment on corrossion and lifetime of used materials and compatibility of tissue implants, polymer materials in medicine used as implants or medicines with gradual release of active substance or with targeted release of medicine (e.g. targeted cytostatics). The subject also deals with hydrogels for contact lenses and other applications. Lectures on measurement of ions and their effects on human organism. The principle and use of NMR for diagnostics and analysis.

Language of instruction

Czech

Number of ECTS credits

5

Mode of study

Not applicable.

Guarantor

doc. Ing. Marie Sedlaříková, CSc.

Department

Department of Electrical and Electronic Technology (UETE)

Learning outcomes of the course unit

Knowledge and skills in the field of material engineering

Prerequisites

Knowledge at secondary school level and of completed subjects in the study area

Co-requisites

Not applicable.

Planned learning activities and teaching methods

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations.

Assesment methods and criteria linked to learning outcomes

Requirements for successful completion of the subject are specified by guarantor’s regulation updated for every academic year.

Course curriculum

1. Basic properties of tissue and bodily fluids. Impact of ions of diffferent elements on their
composition and on the health of man
2. Corrossion and compatibility of materials in living organisms
3. Polymer materials used in biomedical applications, contact and intraocular lenses
4. Form of drugs, targeted cytostatics
5. Materials and thir usage in kardiology
6. Chemical sources of energy for laboratory apparatuses and implants
7. Measurement of the concentration and parameters of positive and negative ions.
Speleotherapy.
8. NMR compatibility of tissues and implants
9. Biocompatibility of tissue implaant. sutural materials, sterilization

Work placements

Not applicable.

Aims

The proposed subject will deepen the knowledge of Bachelor students of electrical engineering of materials and their properties for biomedical applications.

Specification of controlled education, way of implementation and compensation for absences

Extent and forms are specified by guarantor’s regulation updated for every academic year.

Recommended optional programme components

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

Bednář, B. a kol.: Nové materiály, Ediční středisko VŠCHT, Praha 1991 (CS)
Navrátil,L. a kol: Medicínská biofyzika, GRADA 2005, Praha (CS)
Vondrák, J., Sedlaříková,M.,Elektrochemická měření, elektronická verze (CS)
Žabka,M. a kol.:Moderní lékové formy ve farmaceutické technologii, Bratislava 2001 (CS)

Recommended reading

Liu,B. In vitro investigation of Fe30Mn6Si shape memory alloy as potential biodegradable metallic material, Material Letters 65 (2011) 540-543 (EN)

Classification of course in study plans

  • Programme BTBIO-A Bachelor's

    branch A-BTB , 3 year of study, summer semester, compulsory

  • Programme EEKR-CZV lifelong learning

    branch EE-FLE , 1 year of study, summer semester, compulsory

Type of course unit

 

Lecture

26 hod., optionally

Teacher / Lecturer

doc. Ing. Marie Sedlaříková, CSc.

Syllabus

1. Corrossion and compatibility of materials in living organisms, corrossion diagrams,composition of tissue fluids
2. Electrode potentials, impact of metal ions on living tissue
3. Electrodes as sensors of tissue composition, pH measurement, ion selective electrodes
electrochemical sensors in vivo and in vitro
4. Chemical sources for laboratory apparatus and implants, accumulators, maintenance and
characteristics. Gel electrolytes – characteristics, advantages and disadvantages, application
in accumulators
5. Lithium cells, batteries for implants in cardiology, defibrilators
6. Materials for the biological environment. Materials for implants Ceramic, metal and
polymer materials.
7. Hydrogels in biomedical applications, contact with living tissue. Definition of hydrogels advantages over other materials.
8. Contact and intraocular lenses, materials, swelling capacity, mechanical properties, solubility for oxygen, production technology, applications
9. Targeted cytostatics Polymer systems for transport and controlled release of biologically active molecules. Soluble polymer carriers of medicines.Targeted directing of medicines
10. Ions. Impact of positive and negative ions on the human organism. Speleotherapy. Impact of negative ions of the health of man.
11. Parameters of materials in residential premises and their influence on the magnitude of space charge. Influence of clothing materials on the origin and elimination of static charge.
12. NMR compatibility of tissue implants parameters affecting the contrast in the MR image, electric properties of materials for medical applications affecting MR images
13. Monitoring of the influence of tissue implant materials on MR images and their distortion. MR measurement techniques and evaluation of monitored phenomena

Laboratory exercise

26 hod., compulsory

Teacher / Lecturer

doc. Ing. Marie Sedlaříková, CSc.

Syllabus

1. Determination of the content of calcium and nitrates in mineral waters
2. The environmental scanning electron microscope
3. Diagnostics of biomaterials by means of the environmental scanning electron microscope
4. Measurement of discharge characteristics of lithium batteries
5. Measurement of the concentration of air ions in different environments
6. Magnetic resonance
7. Measurement of deformations in magnetic fields due to electrically and magnetically conductive implants
8. Preparation of hydrogels by radical polymerisation and polymerisation by UV
radiation, kinetics of swelling
9. Flade corrossion diagrams: Cu, Zn, N, Au
10, 11, 12, 13. Excursions to hospital laboratories and specialised departments, excursion to the Research Institute of Macromolecular Chemistry of Academy of Sciences