Course detail

Biophysical Chemistry

FCH-MCO_BFCHAcad. year: 2014/2015

The course focuses on the application of basic theoretical knowledge of physical chemistry to the biological systems. It represents a borderline course between physics, chemistry and biology, which allow obtaining molecular and structural perspective on biologically important and medically important pehnomena. Attention is drawn to an impact of the basic theoretical knowledge into analytical (advanced methods of study and interpretation of the structure and function of biopolymers) and application fields.

Language of instruction

Czech

Number of ECTS credits

4

Mode of study

Not applicable.

Learning outcomes of the course unit

Completing the course will result in knowledge on the essential principles of chemical thermodynamics and kinetics and their application to biological systems.

Prerequisites

Not applicable.

Co-requisites

Not applicable.

Planned learning activities and teaching methods

The course uses teaching methods in form of Lecture - 2 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

Assesment methods and criteria linked to learning outcomes

Exam: written and oral

Course curriculum

Syllabus divided to weekly given lectures:

1., 2. Principal concepts and strategy of biophysical chemistry (introduction, structure and function of biomolecules, molecular interactions, cell environment)
3., 4. Conformation of biomolecule (Importance of molecular interactions in living systems, analytical tools)
5., 6. Bioenergetics (thermodynamics of the living systems, binding constants and methods of the determination)
7. Kinetics of biological processes (enzymatic kinetics, kinetics of denaturation, pharmacokinetics)
8. Transport in living systems (mass transport, membrane processes, information transport, osmotic transport, Donnan equilibrium)
9. Phase transfer in biopolymers (dissolution, denaturation, crystallization, phase diagrams)
10., 11. Electrochemistry of biopolymers (activity of polyelectrolytes, dissociation a solvation of bipolymers, vsolování a vysolování bílkovin, Hoffmeister series, buffering of biopolymers – pH of the body fluids,...)
12. Computation methods in the study on structure and dynamics of biopolymers
13. Impact of biophysical chemistry on industrial applications

Work placements

Not applicable.

Aims

The main aim of the course is to apply the basic knowledge and theories of physical chemistry (both from the thermodynamic and kinetic point of view) on the living systems and phenomena.

Specification of controlled education, way of implementation and compensation for absences

Attendance to lectures is not required but is recommended.

Recommended optional programme components

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

Kodíček M. Karpenko V.: Biofysikální chemie. Academia, 2000 (CS)

Recommended reading

Not applicable.

Classification of course in study plans

  • Programme NPCP_MA Master's

    branch NPCO_MA , 1 year of study, winter semester, compulsory-optional

  • Programme NPCP_SCH Master's

    branch NPCO_SCH , 1 year of study, winter semester, compulsory-optional

  • Programme CKCP_CZV lifelong learning

    branch CKCO_CZV , 1 year of study, winter semester, compulsory-optional

Type of course unit

 

Lecture

26 hod., optionally

Teacher / Lecturer