Czech

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Completing the course will result in knowledge on the essential principles of chemical thermodynamics and kinetics and their application to biological systems.

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The course uses teaching methods in form of Lecture - 2 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

Exam: written and oral

Syllabus divided to weekly given lectures:

1., 2. Principal concepts and strategy of biophysical chemistry (introduction, structure and function of biomolecules, molecular interactions, cell environment)
3., 4. Conformation of biomolecule (Importance of molecular interactions in living systems, analytical tools)
5., 6. Bioenergetics (thermodynamics of the living systems, binding constants and methods of the determination)
7. Kinetics of biological processes (enzymatic kinetics, kinetics of denaturation, pharmacokinetics)
8. Transport in living systems (mass transport, membrane processes, information transport, osmotic transport, Donnan equilibrium)
9. Phase transfer in biopolymers (dissolution, denaturation, crystallization, phase diagrams)
10., 11. Electrochemistry of biopolymers (activity of polyelectrolytes, dissociation a solvation of bipolymers, vsolování a vysolování bílkovin, Hoffmeister series, buffering of biopolymers – pH of the body fluids,...)
12. Computation methods in the study on structure and dynamics of biopolymers
13. Impact of biophysical chemistry on industrial applications

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The main aim of the course is to apply the basic knowledge and theories of physical chemistry (both from the thermodynamic and kinetic point of view) on the living systems and phenomena.

Attendance to lectures is not required but is recommended.

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Kodíček M. Karpenko V.: Biofysikální chemie. Academia, 2000 (CS)

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