Czech

Not applicable.

Students will be able to choose a suitable polymeric materials, or any combination thereof, for defined medical applications, design methods of synthesis and preparation of (bio) polymer characterization and testing, including methods of in vitro and in vivo for the intended application.

Macromolecular chemistry, Structure and properties of macromolecules, Polymeric materials

Not applicable.

The course uses teaching methods in form of Lecture - 2 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

Oral examination (70%), which is preceded by a written test to be satisfied at 60%.
Active participation in lessons including seminar work (30%).

1. Biomaterials - introduction, definitions, classification and properties of biomaterials applications in medicine.
2. Biodegradation of polymers, biocompatibility and toxicity - characterization and testing of materials in vitro and in vivo
3. Tissue engineering – principles, methodology, stem cells, interactions of biomaterials with cells, extracellular matrix, drug carriers.
4. Method of scaffold preparation for tissue engineering - lyophilization, 3D printing, electrospinning, solvent casting, foaming, sol-gel, stereolithography, laser sintering, rapid prototyping, etc.
5. General overview of polymeric materials and implants for tissue engineering of bone, nervous and cardiovascular system, skin, tendons, cartilage and menisci.
6. Hydrogels in medicine – rheology, crosslinking, mechanical properties, swelling, applications.
7. Biopolymers I – polysaccharides: cellulose, hyaluronic acid, chitosan, alginate, silk fibroin: properties, modification and applications
8. Biopolymers II - polynucleotide substances (RGD), proteins (collagen, fibrin), polyesters (PHB, PHV), isoprenoids: properties, modification and application
9. Synthetic polymers I (non-degradable) - polyacrylates, polyethylene, silicones, polyurethanes, polyethylene terephthalate: mechanical properties and testing for medical applications
10. Synthetic polymers II (biodegradable) – polyesters (PLA, PGA, PCL, PHB)-polycondenzation, ring opening polymerization, block copolymers, sol-gel transition, catalysts, biodegradation, the application
11. Synthetic polymers III (biodegradable)- polyhydroxyalkanoates, polyester carbonates, polyester amides, polyester urethanes, polypropylen fumarates, polyorthoesters, polyanhydrides, polyalkylcyanoacrylates, polyimino carbonates, inorganic polyphosphazenes and inorganic polyphosphoesters
12. Chemical modification of (bio)polymers– response from functional groups, functionalization of synthetic polymers, binding of biologically active agents, crosslinking
13. Composite polymeric materials and their use in medicine - (nano)fibers and (nano)particles filled polymers, a combination of natural and synthetic polymers, ceramics and metallic biomaterials, sterilization of biomaterials. New biomaterials prepared by self-assembly processes.

Not applicable.

The course will provide students with basic knowledge of polymer materials usable for applications in medicine, their history and the present. Apart from commercially available materials, students will be especially familiar with (bio) polymer materials in the research stage, with their synthesis, sample preparation, characterization and testing in vitro and in vivo, focusing on individual medical applications, especially for tissue engineering.

It is not, but the lectures are recommended.

Not applicable.

Not applicable.

Not applicable.

Guelcher SA, Hollinger JO, editors. An Introduction to Biomaterials. In: The biomedical engineering series, Neuman MR, series editor. Taylor & Francis Group, LLC. Boca Raton, Florida, USA. 2006, pp. 553. ISBN: 0-8493-2282-0. (CS)
Ratner BD, Hoffman AS, Schoen FJ, Lemons JE, editors. Biomaterials Science. An Introduction to Materials in Medicine. 2nd ed., Elsevier Academic press, California USA, London UK. 2004, pp. 851. ISBN: 0-12-582463-7. (CS)
Rieger B, Künkel, Coates GW, Reichardt R, Dinjus E, Zevaco TA, volume editors. Synthetic biodegradable polymers. In: Advances in Polymer Science. Springer-Verlag Berlin Heidelberg. 2012; vol. 245, pp. 364. ISSN: 0065-3195 (CS)