Czech

Not applicable.

Acquired knowledge is a basis for further development and design of new biotechnologies.

Good knowledge of microbiology of yeasts and their metabolism, incl. metabolic control. Basic knowledge of cultivation techniques, bioengineering principles of industrial fermentations ( esp. process kinetics, material and energy balance). Basis of sanitation in the fermentation industry.

Not applicable.

The course uses teaching methods in form of Lecture - 2 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

Students must know well properties in technology used microorganisms, their metabolism and possibility for physiological control of the process. Important is also selection of medium, nutrients and cultivation technique (reactor). It is necessary to apply well knowledge from bioengineering and chemical engineering in process design and process evaluation (balance of raw materials, nutrients, wayter, energy, waste materials).

1. Natural products and compounds - overview industrially significant groups.
2. Primary and secondary metabolism, intermediary control mechanisms.
3. Basic parameters of biotechnological process. Specific features of production of primary and secondary metabolites.
4. Production of organic acids, polysaccharides, sugars and derivatives by microorganisms and plynts.
5. Proteins and enzymes. Enzyme biotechnologies, production of industrially significant enzymes.
6. Biotrenasformations - principle, examples.
7. Antibiotics, cytostatics.
8.Alkaoids - overview, production, legislation.
9. Vitamins - production, technology.
10. Phenolic compounds, lignans, flavonoids, chinones; pigments and terpenes, steroids, carotenoids and their biotechnological production.
11. Plant cell and tissue cultures.
12. Animal cell cultures, tissue cultures and theis applications. Stem cells.

Not applicable.

The aim of the course is extension of knowledge about microorganism abilities to synthesize simple and complicated molecules, enzymes and polymers. The aim is not to know all details about technology but above all to understand well methods leading to affect the process via changing metabolism of carbon or other nutrients and their control. Strerss is put on construction of productive strains.

Knowledge is assessed both by written and by oral exams. Well written test is prerequisite for oral exam.

Not applicable.

Not applicable.

Dubey R.S.: A Textbook of Biotechnology. S. Chand and Co., 4th Edition, 2014 (CS)
Masák J. a kol.: Speciální mikrobní technologie. VŠCHT Praha, Praha 1992. (CS)

D:Rehm,H.-J.,Reed G.: Biotechnology, 12 Vols., 2nd Ed, Wiley, 2008 (CS)
Z:Rehm,H.-J.,Reed G.: Biotechnology: Products of Secondary Metabolism, Vol 7, 2nd Ed, Wiley, Weinheim, 2008 (CS)