The content of the course consists of the following thematic blocks: Basic principles of sampling. Procedures for processing the collected sample: methods of isolation of analytes from the matrix (gas, liquid, solid phase), sample cleaning procedures (destructive, non-destructive), group separation techniques. Application possibilities of instrumental methods used for final determination: UV-VIS spectrophotometers, separation methods (gas and liquid chromatography, electromigration methods), mass spectrometry. Mobile analyzers and on-line measurement systems.