Course detail

Molecular Genetics I

FCH-BC_MOG1Acad. year: 2019/2020

History of molecular genetics. Genetic information and the genetic code. Molecular structure of procaryotic and eucaryotic genome. Replication and transcription of procaryotic and eucaryotic genome. Postranscriptional modification and processing of RNA. Translation and posttranslational processing. Regulation of gene expression. Molecular basis of cancerogenesis (oncogenes, antioncogenes). Molecular mechanisms of mutagenesis and recombination. Mobile elements. Repair mechanisms of damaged DNA. Basic methods of molecular genetics. DNA cloning. Gene engineering and transgenic organisms.

Language of instruction

Czech

Number of ECTS credits

4

Mode of study

Not applicable.

Guarantor

prof. RNDr. Jiří Doškař, CSc.

Department

Institute of Food Science and Biotechnology (ÚCHPBT)

Learning outcomes of the course unit

The basic knowledge of molecular biology, using methods of molecular biology and gene engineering in the research area, in industry, agriculture and medicine.

Prerequisites

The structure and basic functions of living systems, their reproduction, cell chemistry, structure and function of biomacromolecules.

Co-requisites

Not applicable.

Planned learning activities and teaching methods

The course uses teaching methods in form of Lecture - 2 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

Assesment methods and criteria linked to learning outcomes

Oral exam

Course curriculum

History of molecular genetics. Genetic information and the genetic code. Molecular structure of procaryotic and eucaryotic genome. Replication and transcription of procaryotic and eucaryotic genome. Postranscriptional modification and processing of RNA. Translation and posttranslational processing. Regulation of gene expression. Molecular basis of cancerogenesis (oncogenes, antioncogenes). Molecular mechanisms of mutagenesis and recombination. Mobile elements. Repair mechanisms of damaged DNA. Basic methods of molecular genetics. DNA cloning. Gene engineering and transgenic organisms. Gene therapy. Genetic diseases and their diagnostics. Molecular genetics of plants and their use in agriculture.

Work placements

Not applicable.

Aims

This lecture is conceived as an introduction into molecular biology and genetics and gives the explanation of processes on molecular level in relation to the basic functions of living systems. The second part of the lecture is focused on basic methods of molecular genetics and their applications in gene engineering which is a main tool of modern biotechnologies.

Specification of controlled education, way of implementation and compensation for absences

Lectures are optional, no control tests during the semester.

Recommended optional programme components

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

Rosypal S. a kol.: Úvod do molekulární biologie. S. Rosypal, Brno 2006. (CS)
Sundstad P., Simmons M.J. Genetika. Český překlad, Masarykova univerzita, Brno 2009 (CS)

Recommended reading

Watson, J.D. et al.: Recombinant DNA, W.H.Freeman, New York 1992. (CS)

Classification of course in study plans

  • Programme BPCP_CHTPO Bachelor's

    specialization PCH , 3 year of study, winter semester, compulsory-optional
    specialization CHPL , 3 year of study, winter semester, compulsory-optional
    specialization BT , 3 year of study, winter semester, compulsory

  • Programme BPCP_CHCHT Bachelor's

    branch BPCO_CHMN , 3 year of study, winter semester, compulsory-optional

  • Programme BPCP_CHTP Bachelor's

    branch BPCO_CHP , 3 year of study, winter semester, compulsory-optional
    branch BPCO_BT , 3 year of study, winter semester, compulsory

  • Programme BKCP_CHTP Bachelor's

    branch BKCO_PCH , 3 year of study, winter semester, compulsory-optional
    branch BKCO_BT , 3 year of study, winter semester, compulsory

  • Programme BKCP_CHTPO Bachelor's

    specialization CHPL , 3 year of study, winter semester, compulsory-optional
    specialization PCH , 3 year of study, winter semester, compulsory-optional
    specialization BT , 3 year of study, winter semester, compulsory

  • Programme AKREDITACE revize Bachelor's 3 year of study, winter semester, compulsory-optional

  • Programme MITAI Master's

    specialization NBIO , 1 year of study, winter semester, compulsory

  • Programme IT-MSC-2 Master's

    branch MBI , 1 year of study, winter semester, compulsory

  • Programme MITAI Master's

    specialization NSEN , 0 year of study, winter semester, elective
    specialization NVIZ , 0 year of study, winter semester, elective
    specialization NGRI , 0 year of study, winter semester, elective
    specialization NISD , 0 year of study, winter semester, elective
    specialization NSEC , 0 year of study, winter semester, elective
    specialization NCPS , 0 year of study, winter semester, elective
    specialization NHPC , 0 year of study, winter semester, elective
    specialization NNET , 0 year of study, winter semester, elective
    specialization NMAL , 0 year of study, winter semester, elective
    specialization NVER , 0 year of study, winter semester, elective
    specialization NIDE , 0 year of study, winter semester, elective
    specialization NEMB , 0 year of study, winter semester, elective
    specialization NSPE , 0 year of study, winter semester, elective
    specialization NADE , 0 year of study, winter semester, elective
    specialization NMAT , 0 year of study, winter semester, elective
    specialization NISY , 0 year of study, winter semester, elective

Type of course unit

 

Lecture

26 hod., optionally

Teacher / Lecturer

prof. RNDr. Jiří Doškař, CSc.