English

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Students will improve their knowledge about the biopolymers: Extraction from different sources, characterizations and chemical modifications of biopolymers. Medical and environmental applications of biomaterials.

Basic knowledge of organic technology.

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90 % face-to-face, 10 % distance learning

Written test /oral examination/activity participation in lectures (70/20/10)

Lecture 1: Introduction about biopolymers such as cellulose/oxycellulose, starch, chitin, dextrin, chitosan, hyaluronic acid, alginate, chitin-glucan complex, pectin, etc.... and their classifications depend on the following parameters.
 Depend on functionality (amino, carboxylic, hydroxyl, thiol, acetamide, etc….).
 Classification depend on structure (mono, di, branched, etc….).
 Depend applications such as biomedical and environmental purposes.
Lecture 2: Different extraction process of biopolymers:
 Chemically (using different chemical treatment),
 Enzymatically (using different enzymes as glucanase, cellulose, hyaluronidase),
 Mechanically (thermal/mechanical treatment).
Lecture 3: Characterization of biopolymers by different techniques and confirmation the structure by measure:
 Degree of polymerization, degree of deaceytlayion/acetylation, carboxylation, thiolation, oxidation,
 Molecular weight calculation,
 Degree of substitution on the linear or branched chains.
Lecture 4: Chemical modifications of by biopolymers:
 Amidation, esterification, graft copolymerization,
 Quaternization of biopolymers, alkylation, oxidation,
 Photo/chemical/physical cross-linking of the surface of biopolymers like chitin, chitosan, hyaluronic acids, alginate, cellulose, chitosan-glucan complex, silk fibroin, carrageenan to generate new different chemical/physical properties
Lecture 5: Preparation of different forms of biopolymers like:
 Membranes, films, fibers/ fabrics, hydrogel, powders,
 3D structure using freeze thawing, freeze-drying, precipitation,
 Casting, wet/electrospinning techniques.
Lecture 6: The medical uses of biopolymers as:
 Healing/dressing wound, cell carrier,
 Antibacterial agents and for bone/cartilage regenerations,
 Environmental application epically for waste water treatments and removing all hazard metals/organic substance.
Lecture 7: Uses of biomaterial (native/modified) in preparation/synthetization of:
 Different metal/metal oxide nanoparticles as reducing/ stabilizing/capping agents such as,
 Silver nanoparticles,
 Gold nanoparticles and zinc oxide nanoparticles,
 Titanium oxide nanoparticles and nanohydroxy apatite and their applications.
Lecture 8: The mechanisms of interactions between metal/metal oxide nanoparticles and biomaterials (native/modified):
 Stabilizing the metal/metal oxide nanoparticles
 reduction of metal/metal oxide nanoparticles using biopolymers such as cellulose/oxy-cellulose, starch, chitin, dextrin, chitosan, hyaluronic acid, alginate, chitin-glucan complex, pectin
 Prevent the aggregation and agglomeration of metal nanoparticles and,
 Preparation of nanocomposite materials.
Lecture 9: The environmental applications of biopolymers:
 Uses of biopolymers such as chitin, chitosan, cyclodextrin, cellulose and their derivatives on metals and organic material removal,
 Uses of biopolymer nanocomposite on wastewater treatments,
 biopolymer smart coating and sensors
Lecture 10: General overview of biopolymers and implantation process (internal and external applications of biopolymers).
 Biodegradable biopolymers based scaffold for bone tissue engineering,
 Biodegradable polymers based scaffold for cartilage tissue engineering,
 Biodegradable polymers based sheets for skin tissue regeneration.
Lecture 11: The chemical modification between biomaterials (native/modified) with;
 Synthetic polymers (poly-carbolactone, polyvinyl alcohol, polyethylene oxide….),
 Proteins (collagen, peptides) and their applications.

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The main aim of the course is to improve the background of the students how to use the natural sources (animal/non animal) in order to obtain biopolymers and usage in different sectors of our life (medicine, agriculture, pharmaceutics, textile, drug delivery, etc……).

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Alen Walton (Auth.), biopolymers, Elsevier Science,1973,610 (EN)
Farzana Parveen, Recent Advances in Biopolymers, Elsevier, 2016, 281 (EN)
Gerald O. Aspinall (Auth.), Polysaccharides, Pergamon Press, 1970,242 (EN)
Jean-Michel Mérillon (eds.), Polysaccharides: Bioactivity and Biotechnology, Springer International Publishing,2015,2241 Springer International Publishing,2015,2241 • Jean-Michel Mérillon (eds.), Polysaccharides: Bioactivity and Biotechnology, Springer International Publishing,2015,2241 (EN)
Robert H. Marchessault, François Ravenelle, and Xiao Xia Zhu (Eds.), ACS Symposium Volume 934; Polysaccharides for Drug Delivery and Pharmaceutical Applications, American Chemical Society,2006,354 (EN)
Vijay Kumar Thakur, Amar Singh Singha, Surface Modification of Biopolymers, Wiley, 2015, 448 (EN)

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