Czech

Not applicable.

Students will be able to choose suitable biomaterials and their combinations for defined medical applications, to design methods of synthesis, modification and preparation of (bio) polymers including methods of physico-chemical characterization and biological testing.

The student should have the basics of organic and macromolecular chemistry, the advantage is knowledge of the structure and properties of polymeric materials and their composites.

Not applicable.

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations. Teaching is conducted in the form of lectures.

Oral examination (70%), which is preceded by a written test to be satisfied at 60%.
Active participation in the lessons, including passed test (30%)

1. Biomaterials - introduction, definition, classification and application in medicine.
2. Biological properties of biomaterials: Biodegradation of polymers, biocompatibility, toxicity - characterization and testing of materials in vitro and in vivo.
3. Synthetic polymers I - biodegradable - polyesters (PLA, PGA, PCL, PHB, PHV) - polycondenzation, ring opening polymerization, block copolymers, catalysts.
4. Synthetic polymers II - biodegradable - polyhydroxyalkanoates, polyester carbonates, polyesteramides, polyesterurethanes, polypropylene fumarates, polyorthoesters, polyanhydrides, polyalkylcyanoacrylates, polyiminocarbonates, inorganic polyphosphazenes and polyphosphoesters.
5. Chemical modifications of (bio) polymers - reactions according to functional groups, functionalization of synthetic polymers, binding of biologically active substances.
6. Biopolymers I - polysaccharides: cellulose, hyaluronan, chitosan, alginate - properties, modifications and applications.
7. Biopolymers II - polynucleotides (RGD), proteins (collagen, fibrin), silk fibroin - properties, modifications and applications.
8. Hydrogels (in medicine) - swelling, sol-gel transition, rheology, cross-linking, biomechanical properties.
9. Tissue engineering - principles, interaction of biomaterials with cells, cell and drug carriers.
10. Methods of preparation of biomaterials for tissue engineering – freeze-drying, electrospinning, solvent casting, foaming, sol-gel, laser sintering, 3D printing.
11. Chemical analyzes of polymers I: GPC, GC, HPLC, FTIR, UV-VIS, CD.
12. Chemical analysis of polymers II: 1H NMR, 13C NMR, COZY, NOSY, FTIR, DSC, TGA.
13. Imaging techniques: SEM, STEM, TEM, confocal microscopy, fluorescent, AFM, micro (nano) CT.

Not applicable.

The course provides students with a basic overview of biomaterials, their history and present. In addition to commercially available materials, students will be acquainted with (bio) polymeric materials in the research stage, their synthesis, chemical modifications, sample preparation, characterization and testing, both chemical-physical and biological, focusing on individual medical applications, especially in regenerative medicine and tissue engineering.

It is not, but the lectures are recommended.

Not applicable.

Not applicable.

Guelcher SA, Hollinger JO, editors. An Introduction to Biomaterials. In: The biomedical engineering series, Neuman MR, series editor. Taylor & Francis Group, LLC. Boca Raton, Florida, USA. 2006, pp. 553. ISBN: 0-8493-2282-0. (EN)
Rieger B, Künkel, Coates GW, Reichardt R, Dinjus E, Zevaco TA, volume editors. Synthetic biodegradable polymers. In: Advances in Polymer Science. Springer-Verlag Berlin Heidelberg. 2012; vol. 245, pp. 364. ISSN: 0065-3195 (EN)
Vojtová, L.; Wolfová, L.; Jurečková, L.; Kohutová, L. Úvod do tkáňového inženýrství. Česká Republika: MediaBros s.r.o., 2015. s. 19-45. ISBN: 978-80-260-9720- 4. (CS)

Not applicable.