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CESA-SPSTAcad. year: 2022/2023
The course is focused on data statistical analysis including its theoretical (basic principles for statistical estimates and tests) and practical (design of experiments, one- and two-sample tests, correlation and regression analysis, and analysis of variance) aspects. Theory is discussed in direct connection with practical examples provided via commonly used software tools. This course prepares candidates for the sole use of statistical methods in their scientific or routine work.
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Specification of controlled education, way of implementation and compensation for absences
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Lecture
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Syllabus
1. Introduction to statistics. Different types of the statistical tasks (parameters estimation, hypothesis testing, prediction, and classification) – differences and practical use.
2. Statistics and probability. Bayes’ theorem. Sensitivity, specificity, predictive values. ROC curve3. Continuous, ordinal and nominal data. Population and sample of data. Descriptive characteristics. Grafical representation of data. Detection of outliers4. Random variable. Distribution of continuous and descrete variables. Testing of disctribution type. Normal distribution. Transformation of random variable, its goal5. Sample parameters estimation. Central limit theorem, confidence interval and its interpretation. Introduction to hypothesis testing. P-value and its interpretation. Type I and type II error, test power, sample size. Biological vs. statistical significance6. One-sample tests. Paired and unpaired data. Parametric and non-parametric methods7. Two-sample tests. Paired and unpaired data. Parametric and non-parametric methods8. Multiple-sample tests I. Analysis of variance (ANOVA). Goals and assumptions. Generalization9. Multiple-sample tests II. Paired and unpaired data. Parametric and non-parametric methods10. Binary and ordinary data analysis. Contingency table. One-sample binomial test. Multiple-sample tests: Fisher‘s exact test, chi-square test for unpaired data, McNemar test for paired data11. Correlation analysis. Parametric and serial correlation (covariance, correlation coefficients, coefficients of similarity). Correlation and covariance matrix12. Regression analysis. Linear regression. Method of least squares for estimation of regression coefficients. Residual analysis of regression models13. Introduction to design of experiments. Estimation of sample size. Randomization technques. Blinding of the study. Short review of experimental plane types
Computer-assisted exercise
1. Introduction to statistics. Exploration analysis.
2. Exploratory data analysis II.
3. Statistical testing I.
4. Statistical testing II.
5. ANOVA
6. Non-parametric testing methods.
7. Analysis of categorical data.
8. Correlation analysis.
9. Regression analysis.
10. ROC analysis.