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FSI-RBMAcad. year: 2023/2024
The course starts with basic information on structure of cardiovascular system, its anatomy, physiology, histology and atherosclerosis as its most frequent pathology. An overview of basic reological properties of blood is presented, as well as constitutive models for description of its non-Newtonian behaviour. The course presents the structure of relevant soft tissues, ways of its analysis at the level of cells and fibres, impact of the structure on mechanical behaviour of the tissue and possibilities of its constitutive description. All this is applied in computational models of animal cells, arteries and heart chamber, created in ANSYS software. Further, the course deals with technical fundamentals of therapeutic treatments and man-made replacements used at cardio-vascular system (vascular grafts, arterial stents, artificial heart valves, artificial heart pumps). The course deals with their technical principles, materials, production technology and basic requirements of biocompatibility.
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Elearning
Classification of course in study plans
specialization BIO , 2 year of study, winter semester, compulsory
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Syllabus
1. Introduction, contents of the course, mechanical properties of soft biological tissues and their experimental evaluation.2. Fundamental medical information on cardiovascular system.3. Structure and activity of myocardium. Anatomy, histology and physiology of blood vessels.4. Structure and composition of blood vessel wall,its mechanical components. Composition of blood.
5.Physiology of heart (ECG, Starling's law). Characteristics of flow in arteries.
6. Models of blood behaviour, velocity profiles of non-Newtonean liquids, Fahraeus-Lindqvist effect.7. Mechanical properties of cells and their computational modelling.8. Orientation of collagen fibres, their dispersion and waviness..9. Mechanical influence on atherosclerotic processes, principials of medical treatment of sclerotic arterie. Arterial stents.10. Vascular grafts (arterial replacements), types, properties, application, production.11. Natural and artificial heart valves, principles of their function, overview of available products.12. Ventricular assist devices and total artificial hearts. 13.Possibilities of computational modelling of cardiovascular system
Computer-assisted exercise
1.-2. FE model of left ventricle. 3.-4. FE tensegrity model of animal cell. 5.-6. FE model of aorta, residual stress.7.-8. Evaluation of residual stress in arteral wall using volume growth (fictitious temperature) method. 9.-10. Experiment - pulsatile flow in elastic tube, orientation of collagen fibres, constitutive models of arterial wall.11.-12. FSI simulation of blood flow in arteries.13. Formulation of semester projects.