Course detail

Cell-material interactions

CEITEC VUT-DS123Acad. year: 2024/2025

In this course will be reviewed the physicochemical interactions that occurs at the interface between a material and an organic system, with particular focus in the interactions with living cells at different scales. The student will learn the most relevant properties of a material that regulate the responses of the living system and how the physiological environment modify the surface and bulk properties of a material. The fundamental aspects of cell biology, biochemistry and mechanotransduction will be revised to allow the student to understand the complex process of cell adhesion and migration, which have several important implications in biocompatibility, tissue regeneration and cancer metastasis. The student also will learn with practical examples the evolution of the approach in the design of implants, from ‘inert’ materials to materials that regulate specific cellular processes. This course is in particular attractive because it is focused in provide the state of the art of one of the research priorities defined by the regional Smart Specialisation Strategy of the South Moravian region.

Language of instruction

English

Mode of study

Not applicable.

Guarantor

M.Sc. Edgar Benjamin Montufar Jimenez, Ph.D.

Department

Central European Institute of Technology BUT (CEITEC VUT)

Entry knowledge

Knowledge of materials science, chemistry and physics. Basic concepts (middle education) of cell biology.

Rules for evaluation and completion of the course

The course consist in several lectures that may be face-to-face or virtual. In each lecture one topic is reviewed by one student and the topic is discussed in group. At the end of the course each student provides its written feedback. The assessment of the course depends on the quality of the presentation, the active participation in all the lectures and the submission of the feedback on time.

Aims

Not applicable.

Study aids

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

A.J. Engler, S. Sen, H.L. Sweeney, D.E. Discher. Matrix elasticity directs stem cell lineage specification. Cell 2006, 126, 677–689 (EN)
C. Mas-Moruno, M. Espanol, E.B. Montufar, G. Mestres, C. Aparicio, F.J. Gil, M.P. Ginebra. Bioactive ceramic and metallic surfaces for bone engineering. In Biomaterials Surface Science, 2013, Wiley-VCH Verlag GmbH & Co. KGaA (EN)
D.F. Williams. Biocompatibility pathways: biomaterials-induced sterile inflammation, mechanotransduction, and principles of biocompatibility control. ACS Biomater. Sci. Eng. 2017, 3, 2−35 (EN)
D.G. Castner, B.D. Ratner. Biomedical surface science: Foundations to frontiers. Surface Science 500 (2002) 28–60 (EN)
K.S. Masters, K.S. Anseth. Cell–material interactions. Advances in Chemical Engineering 29, 2004, 7-46 (EN)
M. Jager, H.P. Jennissen, M. Haversath, A. Busch, T. Grupp, A. Sowislok, M. Herten. Intrasurgical protein layer on titanium arthroplasty explants: from the big twelve to the implant proteome. Proteomics Clin. Appl. 2019, 13, 1800168 (EN)
P.J. Prendergast, J.R. Britton, P.T. Scannell, A.B. Lennon. Failure of biomaterials in implant fixation. In: Fracture of Nano and Engineering Materials and Structures, 2006, Springer (EN)
S.P. Lyu, D. Untereker. Degradability of polymers for implantable biomedical devices. Int. J. Mol. Sci. 2009, 10, 4033-4065 (EN)

Recommended reading

Not applicable.