Course detail

Pathological Physiology

FEKT-BPC-PFYAcad. year: 2025/2026

Pathological physiology is a science about ethiology and pathogenesis of diseases and pathological states. The ability of pathophysiological thinking makes possible an insight into the logical basis of clinical manifest diseases and states in the participation of analytic and synthetic thought processes. Students will be introduced to the basic causes of illness (physical, chemical and biological, including genetic) and their pathogenetic context.

Language of instruction

Czech

Number of ECTS credits

Mode of study

Not applicable.

Guarantor

MUDr. Michal Jurajda, Ph.D.

Department

Faculty of Medicine, Masaryk University Brno (LF MU)

Entry knowledge

Requires knowledge of human biology at the secondary school level. Students should be able to briefly describe the functionality of basic systems of the human body.

Rules for evaluation and completion of the course

Course credit from the labs is conditioned by compulsory attendance. The final exam focuses on the verification of theoretical knowledge and concepts of pathophysiology.
Laboratory exercises are compulsory. Properly excused absences can be substituted at another time after consultation with the teacher.

Aims

The aim of the course is to familiarize students with the basic principles ethiopathological thinking and their relationship to diseases and pathological states.
The student:
- Can define the scope of pathophysiology
- Can explain the basic concepts of the issue of pathophysiology
- Can discuss the external factors leading to disease (physical, chemical and biological)
- Is able to discuss the nature of frequent pathologies and diseases
- Is able to explain the difference between a monogenic disease of civilization
- Can define the basic concepts of genetics
- Is able to define and discuss the basic concepts of the pathophysiology of various systems of the human organism
- Can explain the concepts of immunodeficiency, hypersensitivity and autoimmunity

Study aids

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

KAŇKOVÁ, Kateřina et al. Patologická fyziologie pro bakalářské studijní programy. Brno: MU Brno, 2003. ISBN 80-2103-112-3. (CS)
VAŠKŮ, Anna et al. Praktikum z patologické fyziologie. 1. vyd. Brno: MU Brno, 2000. ISBN 80-210-2318-X. (CS)

Recommended reading

Not applicable.

Classification of course in study plans

  • Programme BPC-BTB Bachelor's 1 year of study, summer semester, compulsory

Type of course unit

 

Lecture

26 hod., optionally

Teacher / Lecturer

MUDr. Michal Jurajda, Ph.D.

Syllabus

1. The field of pathological physiology – health and disease – ethiology and pathogenesis.
2. External factors of the origin of diseases – physical, chemical and biological pathogenic factors.
3. InflammationThe cell and cellular interactions in pathogenic tissue damage. Healing of wounds. Malignant transformation.
4. Immunity system disorders – immunodeficiency, hypersensitiveness, autoimmunity
5. Fundamentals of genetics – monogenous vs. civilisation diseases
6. Pathophysiology of hematogenesis
7. Pathophysiology of the cardiovascular system
8. Pathophysiology of the respiratory system
9. Pathophysiology of the excretory system
10. Pathophysiology of the digestive system
11. Pathophysiology of hormones
12. Pathophysiology of the nervous and muscular system

Laboratory exercise

26 hod., compulsory

Teacher / Lecturer

MUDr. Michal Jurajda, Ph.D.

Syllabus

1. Principles of work with animals
2. Radiation syndrome I
3. Radiation syndrome II
4. An experimental stomach ulcer
5. Renal ischemic disease
6. Experimental venous thrombosis
7. EKG and arythmia on animal models
8. Spirometric examination of lungs
9. Basics of DNA diagnostics - detection of I/D ACE polymorphism
10. Basics of hematological diagnostics
11. Experimental alloxane diabetes
12. Glucose tolerance test
13. Skin conductivity