The course is focused on modern knowledge of technical diagnostics of machines and equipment. Emphasis is placed on theoretical knowledge of technical diagnostics, such as integration of technical diagnostics into product quality, clarification and description of diagnostic systems, further analysis of diagnostic models, diagnostic signals and division of technical diagnostics according to various aspects. Subsequently, attention is focused on selected diagnostic methods, such as thermodiagnostics and other methods are outlined, which will be discussed in detail in the following subject. Emphasis is always placed on the use of individual diagnostics to assess the condition of a technical object. In this course, the selected and discussed methods are important for understanding multi-parameter diagnostics. The course is supplemented by exercises where the most important topics are properly practiced. There is also a discussion of the results and conclusions in the exercises. The course Technical Diagnostics I is followed by the course Technical Diagnostics II, which is a continuation of the description and analysis of other diagnostic methods suitable for assessing the state of technical objects. By studying both courses the student gains comprehensive knowledge of multiparametric diagnostics of machines and equipment. The findings are also based on the content of Industry 4.0.