The subject provides an extension of basic organic chemistry courses and broadens the horizon of knowledge in selected chapters. It offers the student advanced and modern reactions, insight into practical syntheses and mechanisms of organic reactions. Week 1: Work with chemical literature: introduction to the study of chemical literature, primary, secondary and other sources. Work with patent literature. Database resources. Week 2: Alkenes, Cis- and Trans-addition, overview of addition reactions, Alkynes, reactivity of alkynes, AE, AN and AR addition reactions. 3rd week: Aromatic hydrocarbons, Individual types of SEAr, Aromatic nucleophilic substitution of SNAr, Use of the decomposition of diazonium salts for the preparation of other derivatives. 4th week: Halogen derivatives, SN1, SN2 (kinetics and stereochemistry). Halogen elimination on Csp3 - E1, E2, E1cB mechanism - regiospecificity (Zajcev's rule), sterospecificity. Week 5: Hydroxy compounds-alcohols and phenols. Reactivity of the hydroxyl group, acidity and the influence of the carbon residue on the degree of acidity. Ethers, Typical chemical properties, cleavage of the C-O bond, formation of peroxide compounds. Week 6: Amino compounds, properties – basicity, nucleophilicity, Sandmeyer, Enamines, preparation and reactivity. Week 7: Methods of C-C bond formation. Reactions of organometallic compounds, Organolithne reagents - preparation and stability, basicity, Use of organometals in organic synthesis, Chemistry of magnesium and lithium compounds, Grignard reagents - preparation and properties, reactions with carbonyl derivatives, selectivity of Grignard reactions. Week 8: Methods of C-C bond formation: "cross-coupling" reaction. Reactions using palladium compounds – Suzuki reaction, Stille reaction, Sonogashira reaction, Kumada reaction, Heck reaction. 9-10 week: Methods of C-C bond formation. Aldolization of carbonyl compounds, aldolization and α-substitution, conjugate addition 11th week: Carboxylic acids, functional derivatives of carboxylic acids, esters, acid-base hydrolysis, re-esterification, preparation of amides from esters. Halides – preparation and reactivity, Hoffman decomposition of amides. 12-13 week: Basic principles of identification of chemical structures.