Full-time study

4 years

prof. RNDr. Ivana Márová, CSc.

Chairman :
prof. RNDr. Ivana Márová, CSc.
Councillor internal :
prof. Ing. Stanislav Obruča, Ph.D.
prof. Ing. Adriána Kovalčík, Ph.D.
prof. Ing. Miloslav Pekař, CSc.
doc. Ing. Eva Vítová, Ph.D.
doc. Ing. Pavel Diviš, Ph.D.
prof. Mgr. Václav Brázda, Ph.D.
Councillor external :
doc. Ing. Milan Čertík, Ph.D.
prof. RNDr. Jiří Doškař, CSc.
Ing. Martin Polovka, Ph.D.
prof. Ing. Jana Hajšlová, CSc.

1. Utilization of prokaryotes for biotechnological production of polyhydroxyalkanoates and other high-value metabolites

   Thermophilic prokaryotes reveal numerous unique features which make them extremely interesting for microbial biotechnology. This dissertation work will be focused on the in-depth study of two very interesting thermophilic bacteria – gram-negative bacterium Schlegelella thermodepolymerans and also gram-positive bacterium Aneurinibacillus sp. H1. Both bacterial strains were recently described as very promising producers of polyhydroxyalkanoates – microbial polymers with the potential to replace petrochemical polymers in numerous applications. In this work, production polyhydroxyalkanoates will be studied employing numerous cultivation as well as molecular-biology approaches. Furthermore, tools of metabolic engineering will be used to improve the production of polyhydroxyalkanoates and other high-value metabolites.

   Tutor: Obruča Stanislav, prof. Ing., Ph.D.