Životopis

Vzdělání a akademická kvalifikace

1991-96 Brno University of Technology, Czech Republic

Field: Biomedical Engineering

Degree: Doctor of Philosophy (PhD)

Thesis title: Adaptive Systems for ECG Signal Processing

1986-91 Brno University of Technology

Field: Biomedical Engineering

Degree: Master of Science (MSc)

Přehled zaměstnání

Pedagogická činnost

2005 to present Full Professor, Department of Biomedical Engineering, Brno University of Technology, Brno

• Introduced four new courses Introduction to Medical Informatics, Bioinformatics, Computer-Aided Medical Diagnostics, Advanced Processing of Biological Sequences)
• Created and introduced three new study programs – Bachelor in Biomedical Technology and Bioinformatics (2006), Master in Biomedical Engineering and Bioinformatics (2009), PhD in Biomedical Technology and Bioinformatics (2011)
• Supervised 28 PhD students in Biomedical Engineering, Biocybernetics, and Bioinformatics
• Supervised more than 60 Master’s and Bachelor students in Biomedical Engineering
• Wrote two textbooks on Computer-Aided Medical Decision Making

2002 to 2005 Associate Professor, Department of Biomedical Engineering, Brno University of Technology, Brno

• Lectured courses Data, Models and Simulations in Medicine, Medical Informatics, Computer-Aided Medical Diagnostics

Vědeckovýzkumná činnost

2011-present Senior Researcher and Principal Investigator

• Conducted research in microscopic imaging to study electrophysiology and mechanics of living cardiomyocytes
• Characterized magnetic nanoparticles for cell transfection
• Developed staining of lysosomes by nanoparticle based dyes with low toxicity for long-term cell studies
• Studied migration of adherent cells and non-adherent cells
• Studied growing a monolayer of endothelial cells on a flexible tube
• Applied fluorescence lifetime imaging to study cell physiology
• Lead 2 post-docs, 3 PhD students, and 1 MSc student
• Conducted research in in silico methods for genomics, proteomics and drug design
• Developed algorithms for genomic signal processing for de-novo genome assembly
• Developed machine learning methods for unsupervised genome annotation
• Conducted whole-genome studies of antibiotic resistance of bacteria
• Conducted pharmacophore based mapping of proteins
• Lead 3 postdocs, 4 PhD students, and 2 MSc students

2011-15 Senior Researcher, Electrocardiology Group, St. Anne’s University Hospital, Brno (in co-operation with Mayo Clinic, Rochester, MN, USA)

• Conducted research in microscopic imaging to study electrophysiology and mechanics of living cells
• Developed unique instrumentation for fast fluorescence microscopy with simultaneous use of up to three indicators and two digital cameras
• Lead 15 senior and junior researchers

2001-10 Senior Researcher, Experimental Cardiology Research Group, Brno University of Technology

• Conducted research in experimental technology to study electrophysiology of the isolated heart using optical imaging
• Developed an advanced method for registration of action potentials and calcium concentration in the beating heart using touchless fiber-optics based imaging on single cell level
• Lead 9 researchers

1997-98 Visiting Scientist, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA

• Conducted research in myocardial ischemia using models on isolated hearts
• Conducted animal experiments from surgery through controlled coronary artery occlusion to signal acquisition
• Developed a large set of algorithms for noise suppression, signal segment detection, feature extraction, pattern recognition, heart beat classification
• Lead 2 Masters students

Akademické stáže v zahraničí

• 1997-09-01 - 1998-07-01

  Johns Hopkins University, USA
  vědecký pracovník
  

Univerzitní aktivity

2022 to recent Member of Scientific Board of Brno University of Technology

2021 to recent Member of Scientific Board of Faculty of Electrical Engineering and Computer Science, VSB – Technical University of Ostrava

2018 to present Member, Scientific Board of Czech University of Technology, Prague

2011 to present Chair, Biomedical Technology and Bioinformatics, PhD Program Steering Committee, Brno University of Technology

2003 to present Member, Scientific Board of Faculty of Electrical Engineering and Communication, Brno University of Technology

2008 to present Member, Physiology and Pathological Physiology PhD Program Steering Committee, Faculty of Medicine, Masaryk University

2010 to present Member, Biomedical Informatics PhD Program Steering Committee, 1st Faculty of Medicine, Charles University Prague

2010 to 2024 Chair, Department of Biomedical Engineering, Brno University of Technology

2003 to 2010 Vice-Dean, Faculty of Electrical Engineering and Communication, Brno University of Technology

1992 to present Senior Member, IEEE Engineering in Medicine and Biology Society

2013 to present Member, International Society for Computational Biology

2009 to present Local Liaison Officer for Czech Republic, EURASIP Administrative Committee

2002 to 2023 Member, Board of Society for Biomedical Engineering and Medical Informatics Czech Medical Society

Mimouniverzitní aktivity

Jul 2022 to present Member, Supervisory Board of Czech Science Foundation

Sep 2022 Session Chair, Cardiovascular Mechanics session, Computing in Cardiology 2022

Sep 2021 Conference Chair, Computing in Cardiology 2021

Sep 2019 Session Chair, Artifficial Intelligence in Cardiovascular Imaging session, Computing in Cardiology 2019

Jun 2018 Main Topic Co-Chair, Program Committee, IUPESM World Congress on Medical Physics & Biomedical Engineering 2018

Sep 2017 Session Chair, Cardiovascular Responses session, Computing in Cardiology 2017

Sep 2015 Session Chair, Excitation Contraction Coupling and Contraction session, Computing in Cardiology 2015

Sep 2011 Member of Program Committee, 5th European Conference of the International Federation for Medical and Biological Engineering 2011

Jun 2010 Chair of International Program Committee, 20th Biennial International Conference BIOSIGNAL 2010

2002 to present Member, Editorial Board of Physician and Technology scientific journal

2013 to 2014 Project Leader, Brno University of Technology, responsible for a project "Promoting equal opportunities in HR management at universities", EU grant project No. CZ.1.04/3.4.04/88.00093

2013 to 2015 Founder, Brno University of Technology, responsible for building and management of EDISONKA university kindergarten

2015 to 2018 Community teacher, Volunteered and instructed socially excluded children

Spolupráce s průmyslem

2015 to present Co-founder and CEO, RB Spectral Technologies Ltd, startup oriented to research and development of diagnostics tools for medicine and biology

2013 to 2015 Project Manager, Nejcistejsi Ltd., leader of a project team

Ocenění vědeckou komunitou

2020 Silver Medal for contribution to development of biomedical engineering, Brno University of Technology, Czech Republic

2016 Winner of National Startup Competition for the best innovation in the Czech Republic, Czech Innovation Festival, Prague, Czech Republic

2003 Awardee of NATO Science Fellowships Programme, United Kingdom

2002 Rector's Award, Brno University of Technology, Czech Republic

1997 Awardee of J.W. Fulbright Commission Research Fellowship, USA

1995 Awardee of Minister of Education for contribution to research in Czech Republic

Projekty

2018-2020 Principal investigator, Quantitative Phase Microscopy for 3D Qualitative Characterization of Cancer Cells, Czech Science Foundation grant project No. 18-24089S, € 426,000, Project partner: Masaryk University, Brno

2017-2019 Co-investigator, Relationship Between Butanol Efflux and Butanol Tolerance of Clostridia, Czech Science Foundation grant project No. 17-00551S, € 424,000, Project partner: University of Chemistry and Technology, Prague

2011-2015 Principal investigator, Nano-Electro-Bio-Tools for Biochemical and Molecular-Biological Studies of Eukaryotic Cells, Czech Science Foundation grant project No. 102/11/1068, € 962,000, Project partner: Mendel University, Brno

2013-2014 Co-investigator, Advanced Lung Research for Veterinary Medicine of Particles for Inhalation, European Territorial Co-operation Austria-Czech, Republic 2007 – 2013 Programme grant project No. M00250, € 430,000, Project partner: University of Applied Sciences, Vienna, Austria

2010-2012 Co-investigator, Technology for Transplantology, Ministry of Industry and Trade of the Czech Republic grant project No. FR-TI2/596, € 900,000, Project partner: BLOCK a.s., Prague

2009-2012, Principal investigator, Information Technology in Biomedical Engineering, Czech Science Foundation grant project No. 102/09/H083, € 548,000, Project partner: Masaryk University, Brno

2007-2011 Principal investigator, Optical Methods of Registration of Electrical Potentials and Calcium Concentration in the Heart with Laser Stabilization, Czech Science Foundation grant project No. 102/07/1473, € 249,000, Project partner: Masaryk University, Brno